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| 19.02.2022 | 21:00 | Arsenal de Sarandí | - | Huracán | 2:1 (1:1) | |
| 23:15 | Estudiantes | - | Lanús | 2:1 (1:0) | ||
| 20.02.2022 | 01:30 | Vélez Sarsfield | - | Independiente | 0:0 (0:0) | |
| 21:00 | Platense | - | Sarmiento de Junín | 2:0 (0:0) | ||
| 23:15 | Boca Juniors | - | Rosario Central | 2:1 (0:0) | ||
| 21.02.2022 | 01:30 | Newell's Old Boys | - | River Plate | 0:2 (0:0) | |
| 21:00 | Barracas Central | - | Tigre | 0:2 (0:1) | ||
| 23:15 | Banfield | - | Gimnasia de La Plata | 4:0 (1:0) | ||
| 23:15 | Godoy Cruz | - | Aldosivi | 0:2 (0:1) | ||
| 22.02.2022 | 01:30 | San Lorenzo | - | Defensa y Justicia | 3:4 (0:2) | |
| 23:15 | Patronato de Paraná | - | Talleres de Córdoba | 0:0 (0:0) | ||
| 23:15 | Unión de Santa Fe | - | Atlético Tucumán | 1:0 (0:0) | ||
| 23.02.2022 | 01:30 | Racing Club | - | Argentinos Juniors | 3:0 (1:0) | |
| 01:30 | Central Córdoba SdE | - | Colón de Santa Fe | 0:2 (0:0) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Platense | 3 | 2 | 1 | 0 | 5:2 | 3 | 7 |
| 2 |
|
Unión de Santa Fe | 3 | 2 | 1 | 0 | 2:0 | 2 | 7 |
| 3 |
|
River Plate | 3 | 2 | 0 | 1 | 6:2 | 4 | 6 |
| 4 |
|
Argentinos Juniors | 3 | 2 | 0 | 1 | 4:3 | 1 | 6 |
| 5 |
|
Banfield | 3 | 1 | 2 | 0 | 6:2 | 4 | 5 |
| 6 |
|
Racing Club | 3 | 1 | 2 | 0 | 5:2 | 3 | 5 |
| 7 |
|
Defensa y Justicia | 3 | 1 | 1 | 1 | 6:6 | 0 | 4 |
| 8 |
|
Sarmiento de Junín | 3 | 1 | 1 | 1 | 3:4 | -1 | 4 |
| 9 |
|
Gimnasia de La Plata | 3 | 1 | 1 | 1 | 1:4 | -3 | 4 |
| 10 |
|
Newell's Old Boys | 3 | 1 | 0 | 2 | 1:5 | -4 | 3 |
| 11 |
|
Talleres de Córdoba | 3 | 0 | 2 | 1 | 0:1 | -1 | 2 |
| 12 |
|
San Lorenzo | 3 | 0 | 1 | 2 | 3:5 | -2 | 1 |
| 13 |
|
Atlético Tucumán | 3 | 0 | 1 | 2 | 2:4 | -2 | 1 |
| 14 |
|
Patronato de Paraná | 3 | 0 | 1 | 2 | 1:5 | -4 | 1 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 3 | 3 | 0 | 0 | 7:4 | 3 | 9 |
| 2 |
|
Colón de Santa Fe | 3 | 2 | 1 | 0 | 6:2 | 4 | 7 |
| 3 |
|
Boca Juniors | 3 | 2 | 1 | 0 | 5:3 | 2 | 7 |
| 4 |
|
Tigre | 3 | 1 | 2 | 0 | 4:2 | 2 | 5 |
| 5 |
|
Vélez Sarsfield | 3 | 1 | 1 | 1 | 2:1 | 1 | 4 |
| 6 |
|
Central Córdoba SdE | 3 | 1 | 1 | 1 | 4:4 | 0 | 4 |
| 7 |
|
Arsenal de Sarandí | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 |
|
Rosario Central | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 | |
| 9 |
|
Independiente | 3 | 1 | 1 | 1 | 2:2 | 0 | 4 |
| 10 |
|
Lanús | 3 | 1 | 0 | 2 | 3:3 | 0 | 3 |
| 11 |
|
Huracán | 3 | 1 | 0 | 2 | 4:5 | -1 | 3 |
| 12 |
|
Aldosivi | 3 | 1 | 0 | 2 | 3:4 | -1 | 3 |
| 13 |
|
Godoy Cruz | 3 | 0 | 1 | 2 | 2:6 | -4 | 1 |
| 14 |
|
Barracas Central | 3 | 0 | 0 | 3 | 1:7 | -6 | 0 |
| Play-offs | |
| Play-offs |
