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| 06.05.2000 | 20:00 | Sint-Truidense VV | - | Lierse SK | 2:1 (2:1) | |
| 20:00 | K.S.C. Eendracht Aalst | - | RSC Charleroi | 0:3 (0:1) | ||
| 20:00 | KV Mechelen | - | KAA Gent | 0:2 (0:2) | ||
| 20:00 | Club Brugge KV | - | Lommelse SK | 3:1 (0:0) | ||
| 20:00 | Germinal Beerschot | - | Excelsior Mouscron | 0:1 (0:0) | ||
| 20:00 | KRC Harelbeke | - | KRC Genk | 1:2 (0:1) | ||
| 20:00 | KVC Westerlo | - | Verbroedering Geel | 4:1 (1:0) | ||
| 20:00 | Sporting Lokeren | - | KSK Beveren | 5:2 (2:0) | ||
| 20:00 | RSC Anderlecht | - | Standard Luik | 2:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 33 | 22 | 8 | 3 | 85:35 | 50 | 74 |
| 2 |
|
Club Brugge KV | 33 | 20 | 4 | 9 | 68:32 | 36 | 64 |
| 3 |
|
KAA Gent | 33 | 20 | 3 | 10 | 76:51 | 25 | 63 |
| 4 |
|
Excelsior Mouscron | 33 | 16 | 8 | 9 | 66:44 | 22 | 56 |
| 5 |
|
Standard Luik | 33 | 18 | 2 | 13 | 65:49 | 16 | 56 |
| 6 |
|
KVC Westerlo | 33 | 15 | 8 | 10 | 70:64 | 6 | 53 |
| 7 |
|
Lierse SK | 33 | 15 | 7 | 11 | 64:45 | 19 | 52 |
| 8 |
|
Germinal Beerschot | 33 | 15 | 7 | 11 | 52:44 | 8 | 52 |
| 9 |
|
KRC Genk | 33 | 15 | 6 | 12 | 60:58 | 2 | 51 |
| 10 |
|
Sporting Lokeren | 33 | 11 | 11 | 11 | 54:57 | -3 | 44 |
| 11 |
|
KV Mechelen | 33 | 12 | 5 | 16 | 46:74 | -28 | 41 |
| 12 |
|
Sint-Truidense VV | 33 | 10 | 7 | 16 | 40:61 | -21 | 37 |
| 13 |
|
K.S.C. Eendracht Aalst | 33 | 11 | 3 | 19 | 52:71 | -19 | 36 |
| 14 |
|
KSK Beveren | 33 | 9 | 8 | 16 | 50:65 | -15 | 35 |
| 15 |
|
KRC Harelbeke | 33 | 9 | 5 | 19 | 53:71 | -18 | 32 |
| 16 |
|
RSC Charleroi | 33 | 7 | 9 | 17 | 41:61 | -20 | 30 |
| 17 |
|
Verbroedering Geel | 33 | 5 | 13 | 15 | 32:58 | -26 | 28 |
| 18 |
|
Lommelse SK | 33 | 4 | 12 | 17 | 31:65 | -34 | 24 |
