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| 06.12.1980 | K Waterschei SV Thor Genk | - | Sporting Lokeren | 1:1 | ||
| Standard Luik | - | KV Kortrijk | 1:1 | |||
| KSK Beveren | - | RWD Molenbeek | 3:0 | |||
| RSC Anderlecht | - | FC Beringen | 2:1 | |||
| 07.12.1980 | KSV Waregem | - | RFC Liège | 1:1 | ||
| KAA Gent | - | K. Beerschot VAV | 1:1 | |||
| Cercle Brugge | - | KFC Winterslag | 0:1 | |||
| 14.01.1981 | Berchem Sport | - | Lierse SK | 1:6 | ||
| Royal Antwerp FC | - | Club Brugge KV | 3:2 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 15 | 13 | 1 | 1 | 35:10 | 25 | 27:3 |
| 2 |
|
KSK Beveren | 15 | 10 | 3 | 2 | 30:11 | 19 | 23:7 |
| 3 |
|
Standard Luik | 15 | 8 | 4 | 3 | 32:20 | 12 | 20:10 |
| 4 |
|
Sporting Lokeren | 15 | 8 | 2 | 5 | 25:17 | 8 | 18:12 |
| 5 |
|
Club Brugge KV | 15 | 7 | 2 | 6 | 28:23 | 5 | 16:14 |
| 6 |
|
KV Kortrijk | 15 | 7 | 2 | 6 | 23:24 | -1 | 16:14 |
| 7 |
|
RWD Molenbeek | 15 | 7 | 2 | 6 | 19:22 | -3 | 16:14 |
| 8 |
|
Lierse SK | 15 | 6 | 4 | 5 | 29:23 | 6 | 16:14 |
| 9 |
|
KSV Waregem | 15 | 6 | 3 | 6 | 21:21 | 0 | 15:15 |
| 10 |
|
KFC Winterslag | 15 | 7 | 1 | 7 | 20:20 | 0 | 15:15 |
| 11 |
|
Royal Antwerp FC | 15 | 5 | 5 | 5 | 21:28 | -7 | 15:15 |
| 12 |
|
Cercle Brugge | 15 | 5 | 3 | 7 | 22:30 | -8 | 13:17 |
| 13 |
|
Berchem Sport | 15 | 4 | 5 | 6 | 16:26 | -10 | 13:17 |
| 14 |
|
KAA Gent | 15 | 4 | 4 | 7 | 19:20 | -1 | 12:18 |
| 15 |
|
K Waterschei SV Thor Genk | 15 | 5 | 2 | 8 | 26:32 | -6 | 12:18 |
| 16 |
|
RFC Liège | 15 | 3 | 2 | 10 | 17:24 | -7 | 8:22 |
| 17 |
|
K. Beerschot VAV | 15 | 3 | 2 | 10 | 14:26 | -12 | 8:22 |
| 18 |
|
FC Beringen | 15 | 2 | 3 | 10 | 16:36 | -20 | 7:23 |
