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| 11.04.1981 | K Waterschei SV Thor Genk | - | RFC Liège | 0:2 | ||
| KSV Waregem | - | KV Kortrijk | 0:0 | |||
| KSK Beveren | - | KFC Winterslag | 0:2 | |||
| RSC Anderlecht | - | K. Beerschot VAV | 8:2 | |||
| 12.04.1981 | Standard Luik | - | Lierse SK | 2:0 | ||
| KAA Gent | - | RWD Molenbeek | 2:1 | |||
| Club Brugge KV | - | FC Beringen | 2:0 | |||
| Berchem Sport | - | Cercle Brugge | 0:2 | |||
| Royal Antwerp FC | - | Sporting Lokeren | 0:1 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 29 | 22 | 5 | 2 | 67:19 | 48 | 49:9 |
| 2 |
|
Sporting Lokeren | 29 | 16 | 6 | 7 | 58:31 | 27 | 38:20 |
| 3 |
|
KSK Beveren | 29 | 16 | 6 | 7 | 46:27 | 19 | 38:20 |
| 4 |
|
Standard Luik | 29 | 15 | 5 | 9 | 53:40 | 13 | 35:23 |
| 5 |
|
Club Brugge KV | 29 | 14 | 4 | 11 | 63:46 | 17 | 32:26 |
| 6 |
|
KFC Winterslag | 29 | 13 | 5 | 11 | 38:39 | -1 | 31:27 |
| 7 |
|
KAA Gent | 29 | 11 | 8 | 10 | 45:40 | 5 | 30:28 |
| 8 |
|
Royal Antwerp FC | 29 | 10 | 10 | 9 | 37:41 | -4 | 30:28 |
| 9 |
|
RWD Molenbeek | 29 | 12 | 5 | 12 | 40:42 | -2 | 29:29 |
| 10 |
|
Lierse SK | 29 | 9 | 11 | 9 | 47:43 | 4 | 29:29 |
| 11 |
|
KSV Waregem | 29 | 9 | 9 | 11 | 35:38 | -3 | 27:31 |
| 12 |
|
RFC Liège | 29 | 9 | 7 | 13 | 43:39 | 4 | 25:33 |
| 13 |
|
KV Kortrijk | 29 | 9 | 7 | 13 | 34:48 | -14 | 25:33 |
| 14 |
|
Cercle Brugge | 29 | 9 | 6 | 14 | 43:57 | -14 | 24:34 |
| 15 |
|
K Waterschei SV Thor Genk | 29 | 9 | 4 | 16 | 45:62 | -17 | 22:36 |
| 16 |
|
K. Beerschot VAV | 29 | 7 | 6 | 16 | 32:47 | -15 | 20:38 |
| 17 |
|
FC Beringen | 29 | 6 | 7 | 16 | 31:56 | -25 | 19:39 |
| 18 |
|
Berchem Sport | 29 | 5 | 9 | 15 | 24:66 | -42 | 19:39 |
