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| 10.12.1988 | 20:00 | RSC Charleroi | - | RFC Liège | 1:1 (0:0) | |
| 20:00 | K. Beerschot VAV | - | Sporting Lokeren | 2:2 (1:0) | ||
| 20:00 | RSC Anderlecht | - | KRC Genk | 6:1 (3:0) | ||
| 11.12.1988 | 15:00 | Standard Luik | - | KSV Waregem | 2:1 (1:1) | |
| 15:00 | KRC Mechelen | - | Club Brugge KV | 1:1 (0:1) | ||
| 15:00 | RWD Molenbeek | - | Sint-Truidense VV | 1:2 (0:0) | ||
| 15:00 | KV Kortrijk | - | Lierse SK | 4:1 (0:0) | ||
| 15:00 | Cercle Brugge | - | KV Mechelen | 0:2 (0:0) | ||
| 15:00 | KSK Beveren | - | Royal Antwerp FC | 1:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KV Mechelen | 18 | 13 | 4 | 1 | 34:13 | 21 | 30:6 |
| 2 |
|
RSC Anderlecht | 18 | 13 | 3 | 2 | 44:16 | 28 | 29:7 |
| 3 |
|
RFC Liège | 18 | 10 | 6 | 2 | 39:14 | 25 | 26:10 |
| 4 |
|
Club Brugge KV | 18 | 10 | 4 | 4 | 39:19 | 20 | 24:12 |
| 5 |
|
Royal Antwerp FC | 18 | 8 | 7 | 3 | 34:24 | 10 | 23:13 |
| 6 |
|
Sint-Truidense VV | 18 | 9 | 4 | 5 | 23:23 | 0 | 22:14 |
| 7 |
|
KV Kortrijk | 18 | 7 | 5 | 6 | 31:25 | 6 | 19:17 |
| 8 |
|
Standard Luik | 18 | 6 | 6 | 6 | 25:26 | -1 | 18:18 |
| 9 |
|
KSV Waregem | 18 | 7 | 3 | 8 | 26:28 | -2 | 17:19 |
| 10 |
|
RSC Charleroi | 18 | 4 | 7 | 7 | 17:29 | -12 | 15:21 |
| 11 |
|
Sporting Lokeren | 18 | 5 | 5 | 8 | 23:26 | -3 | 15:21 |
| 12 |
|
K. Beerschot VAV | 18 | 4 | 6 | 8 | 20:28 | -8 | 14:22 |
| 13 |
|
KSK Beveren | 18 | 4 | 5 | 9 | 19:26 | -7 | 13:23 |
| 14 |
|
KRC Mechelen | 18 | 4 | 5 | 9 | 22:32 | -10 | 13:23 |
| 15 |
|
RWD Molenbeek | 18 | 5 | 3 | 10 | 16:29 | -13 | 13:23 |
| 16 |
|
Lierse SK | 18 | 4 | 5 | 9 | 13:28 | -15 | 13:23 |
| 17 |
|
Cercle Brugge | 18 | 3 | 4 | 11 | 18:30 | -12 | 10:26 |
| 18 |
|
KRC Genk | 18 | 2 | 6 | 10 | 10:37 | -27 | 10:26 |
