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| 03.03.2006 | 20:30 | Sporting Charleroi | - | KSK Beveren | 4:0 (2:0) | |
| 04.03.2006 | 18:00 | Sporting Lokeren | - | Club Brugge KV | 2:0 (1:0) | |
| 20:00 | Cercle Brugge | - | KRC Genk | 1:1 (0:0) | ||
| 20:00 | RAA La Louviére | - | Excelsior Mouscron | 0:0 (0:0) | ||
| 20:00 | KVC Westerlo | - | Sint-Truidense VV | 2:1 (0:1) | ||
| 20:00 | SV Zulte Waregem | - | FC Brussels | 0:0 (0:0) | ||
| 20:00 | KAA Gent | - | KSV Roeselare | 1:2 (1:1) | ||
| 05.03.2006 | 18:00 | RSC Anderlecht | - | Lierse SK | 3:0 (0:0) | |
| 20:30 | Standard Luik | - | Germinal Beerschot | 3:1 (2:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 25 | 15 | 7 | 3 | 54:22 | 32 | 52 |
| 2 |
|
Standard Luik | 25 | 15 | 5 | 5 | 45:23 | 22 | 50 |
| 3 |
|
Club Brugge KV | 25 | 13 | 8 | 4 | 39:24 | 15 | 47 |
| 4 |
|
SV Zulte Waregem | 25 | 13 | 5 | 7 | 43:34 | 9 | 44 |
| 5 |
|
KRC Genk | 25 | 11 | 8 | 6 | 43:30 | 13 | 41 |
| 6 |
|
KVC Westerlo | 25 | 11 | 5 | 9 | 34:30 | 4 | 38 |
| 7 |
|
Sporting Lokeren | 25 | 10 | 8 | 7 | 37:34 | 3 | 38 |
| 8 |
|
KAA Gent | 25 | 11 | 5 | 9 | 32:29 | 3 | 38 |
| 9 |
|
Sporting Charleroi | 25 | 9 | 7 | 9 | 27:29 | -2 | 34 |
| 10 |
|
FC Brussels | 25 | 8 | 9 | 8 | 25:25 | 0 | 33 |
| 11 |
|
KSV Roeselare | 25 | 8 | 8 | 9 | 39:33 | 6 | 32 |
| 12 |
|
Germinal Beerschot | 25 | 9 | 4 | 12 | 37:40 | -3 | 31 |
| 13 |
|
Cercle Brugge | 25 | 7 | 5 | 13 | 30:49 | -19 | 26 |
| 14 |
|
Excelsior Mouscron | 25 | 7 | 4 | 14 | 31:36 | -5 | 25 |
| 15 |
|
Sint-Truidense VV | 25 | 5 | 8 | 12 | 26:37 | -11 | 23 |
| 16 |
|
RAA La Louviére | 25 | 4 | 10 | 11 | 21:45 | -24 | 22 |
| 17 |
|
Lierse SK | 25 | 5 | 7 | 13 | 16:41 | -25 | 22 |
| 18 |
|
KSK Beveren | 25 | 6 | 3 | 16 | 26:44 | -18 | 21 |
