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| 07.11.2008 | 20:30 | Cercle Brugge | - | SV Zulte Waregem | 2:0 (0:0) | |
| 08.11.2008 | 20:00 | KAA Gent | - | FCV Dender EH | 1:1 (1:0) | |
| 20:00 | KVC Westerlo | - | KRC Genk | 1:0 (0:0) | ||
| 20:00 | KSV Roeselare | - | AFC Tubize | 1:2 (1:1) | ||
| 20:00 | RSC Anderlecht | - | Sporting Lokeren | 2:3 (0:2) | ||
| 20:00 | KV Kortrijk | - | KV Mechelen | 0:0 (0:0) | ||
| 20:00 | RAEC Mons | - | Excelsior Mouscron | 0:0 (0:0) | ||
| 09.11.2008 | 18:00 | Sporting Charleroi | - | Club Brugge KV | 2:2 (0:0) | |
| 20:30 | Germinal Beerschot | - | Standard Luik | 1:3 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Brugge KV | 11 | 7 | 3 | 1 | 21:10 | 11 | 24 |
| 2 |
|
Standard Luik | 11 | 7 | 2 | 2 | 19:11 | 8 | 23 |
| 3 |
|
RSC Anderlecht | 11 | 7 | 1 | 3 | 28:15 | 13 | 22 |
| 4 |
|
KVC Westerlo | 11 | 6 | 3 | 2 | 16:12 | 4 | 21 |
| 5 |
|
KRC Genk | 11 | 6 | 2 | 3 | 17:12 | 5 | 20 |
| 6 |
|
KAA Gent | 11 | 5 | 4 | 2 | 22:12 | 10 | 19 |
| 7 |
|
Sporting Lokeren | 11 | 4 | 6 | 1 | 14:8 | 6 | 18 |
| 8 |
|
Excelsior Mouscron | 11 | 5 | 3 | 3 | 17:12 | 5 | 18 |
| 9 |
|
Cercle Brugge | 11 | 5 | 1 | 5 | 16:16 | 0 | 16 |
| 10 |
|
Sporting Charleroi | 11 | 4 | 3 | 4 | 13:15 | -2 | 15 |
| 11 |
|
SV Zulte Waregem | 11 | 4 | 1 | 6 | 13:14 | -1 | 13 |
| 12 |
|
KV Kortrijk | 11 | 3 | 4 | 4 | 10:18 | -8 | 13 |
| 13 |
|
RAEC Mons | 11 | 2 | 4 | 5 | 9:14 | -5 | 10 |
| 14 |
|
FCV Dender EH | 11 | 2 | 4 | 5 | 15:21 | -6 | 10 |
| 15 |
|
KV Mechelen | 11 | 2 | 3 | 6 | 12:22 | -10 | 9 |
| 16 |
|
Germinal Beerschot | 11 | 1 | 5 | 5 | 10:14 | -4 | 8 |
| 17 |
|
AFC Tubize | 11 | 2 | 1 | 8 | 9:22 | -13 | 7 |
| 18 |
|
KSV Roeselare | 11 | 1 | 2 | 8 | 6:19 | -13 | 5 |
| Champions League Kwali. | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
