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| 19.12.2008 | 20:30 | RSC Anderlecht | - | KRC Genk | 2:0 (1:0) | |
| 20.12.2008 | 20:00 | Germinal Beerschot | - | AFC Tubize | 2:0 (1:0) | |
| 20:00 | Sporting Lokeren | - | KV Mechelen | 2:2 (1:0) | ||
| 20:00 | Sporting Charleroi | - | FCV Dender EH | 2:0 (1:0) | ||
| 20:00 | Cercle Brugge | - | KSV Roeselare | 4:3 (3:0) | ||
| 20:00 | RAEC Mons | - | SV Zulte Waregem | 2:2 (1:1) | ||
| 20:00 | Excelsior Mouscron | - | Club Brugge KV | 5:1 (3:1) | ||
| 21.12.2008 | 18:00 | KV Kortrijk | - | KVC Westerlo | 0:0 (0:0) | |
| 20:30 | Standard Luik | - | KAA Gent | 2:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 17 | 12 | 2 | 3 | 43:17 | 26 | 38 |
| 2 |
|
Standard Luik | 17 | 10 | 4 | 3 | 30:17 | 13 | 34 |
| 3 |
|
Club Brugge KV | 17 | 9 | 4 | 4 | 29:23 | 6 | 31 |
| 4 |
|
KRC Genk | 17 | 9 | 3 | 5 | 26:22 | 4 | 30 |
| 5 |
|
KVC Westerlo | 17 | 8 | 4 | 5 | 22:20 | 2 | 28 |
| 6 |
|
Cercle Brugge | 17 | 9 | 1 | 7 | 29:28 | 1 | 28 |
| 7 |
|
Sporting Lokeren | 17 | 6 | 9 | 2 | 22:14 | 8 | 27 |
| 8 |
|
Excelsior Mouscron | 17 | 8 | 3 | 6 | 28:22 | 6 | 27 |
| 9 |
|
SV Zulte Waregem | 17 | 7 | 3 | 7 | 25:23 | 2 | 24 |
| 10 |
|
KAA Gent | 17 | 6 | 5 | 6 | 33:24 | 9 | 23 |
| 11 |
|
KV Kortrijk | 17 | 5 | 7 | 5 | 18:24 | -6 | 22 |
| 12 |
|
Sporting Charleroi | 17 | 6 | 3 | 8 | 22:26 | -4 | 21 |
| 13 |
|
KV Mechelen | 17 | 4 | 6 | 7 | 19:28 | -9 | 18 |
| 14 |
|
RAEC Mons | 17 | 3 | 6 | 8 | 19:24 | -5 | 15 |
| 15 |
|
Germinal Beerschot | 17 | 3 | 6 | 8 | 18:23 | -5 | 15 |
| 16 |
|
FCV Dender EH | 17 | 3 | 6 | 8 | 21:33 | -12 | 15 |
| 17 |
|
AFC Tubize | 17 | 4 | 2 | 11 | 20:36 | -16 | 14 |
| 18 |
|
KSV Roeselare | 17 | 2 | 4 | 11 | 13:33 | -20 | 10 |
| Champions League Kwali. | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
