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| 01.10.2021 | 21:00 | SD Ponferradina | - | Real Valladolid | 2:2 (0:0) | |
| 02.10.2021 | 16:00 | SD Amorebieta | - | Sporting Gijón | 1:1 (1:0) | |
| 16:00 | SD Huesca | - | CD Tenerife | 1:2 (1:1) | ||
| 18:15 | Real Zaragoza | - | Real Oviedo | 0:0 (0:0) | ||
| 21:00 | AD Alcorcón | - | Real Sociedad B | 1:4 (1:2) | ||
| 03.10.2021 | 14:00 | SD Eibar | - | UD Ibiza | 3:1 (1:1) | |
| 16:00 | Málaga CF | - | CF Fuenlabrada | 1:0 (1:0) | ||
| 18:15 | Burgos CF | - | CD Mirandés | 1:0 (1:0) | ||
| 18:15 | UD Las Palmas | - | FC Cartagena | 4:1 (3:0) | ||
| 21:00 | CD Leganés | - | CD Lugo | 1:1 (0:0) | ||
| 04.10.2021 | 21:00 | Girona FC | - | UD Almería | 1:2 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 8 | 6 | 0 | 2 | 17:7 | 10 | 18 |
| 2 |
|
Sporting Gijón | 8 | 5 | 2 | 1 | 12:8 | 4 | 17 |
| 3 |
|
SD Ponferradina | 8 | 5 | 1 | 2 | 12:7 | 5 | 16 |
| 4 |
|
CD Tenerife | 8 | 4 | 2 | 2 | 10:7 | 3 | 14 |
| 5 |
|
SD Eibar | 8 | 4 | 2 | 2 | 12:10 | 2 | 14 |
| 6 |
|
UD Las Palmas | 8 | 3 | 4 | 1 | 12:9 | 3 | 13 |
| 7 |
|
UD Ibiza | 8 | 2 | 5 | 1 | 10:9 | 1 | 11 |
| 8 |
|
Málaga CF | 8 | 3 | 2 | 3 | 7:10 | -3 | 11 |
| 9 |
|
Real Valladolid | 8 | 3 | 2 | 3 | 9:9 | 0 | 11 |
| 10 |
|
Real Oviedo | 8 | 2 | 5 | 1 | 8:6 | 2 | 11 |
| 11 |
|
CF Fuenlabrada | 8 | 2 | 4 | 2 | 7:6 | 1 | 10 |
| 12 |
|
CD Mirandés | 8 | 3 | 1 | 4 | 11:11 | 0 | 10 |
| 13 |
|
SD Huesca | 8 | 3 | 1 | 4 | 11:9 | 2 | 10 |
| 14 |
|
Real Sociedad B | 8 | 2 | 3 | 3 | 8:8 | 0 | 9 |
| 15 |
|
CD Leganés | 8 | 2 | 3 | 3 | 7:8 | -1 | 9 |
| 16 |
|
FC Cartagena | 8 | 3 | 0 | 5 | 7:14 | -7 | 9 |
| 17 |
|
Burgos CF | 8 | 2 | 3 | 3 | 6:6 | 0 | 9 |
| 18 |
|
CD Lugo | 8 | 1 | 5 | 2 | 9:11 | -2 | 8 |
| 19 |
|
Real Zaragoza | 8 | 1 | 5 | 2 | 5:7 | -2 | 8 |
| 20 |
|
Girona FC | 8 | 2 | 2 | 4 | 6:8 | -2 | 8 |
| 21 |
|
SD Amorebieta | 8 | 1 | 4 | 3 | 7:11 | -4 | 7 |
| 22 |
|
AD Alcorcón | 8 | 1 | 0 | 7 | 5:17 | -12 | 3 |
| Promotie | |
| Play-offs | |
| Degradatie |
