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| 12.02.2022 | 14:30 | Latina Calcio | - | FC Turris | 3:1 (2:1) | |
| 17:30 | ACR Messina | - | Foggia Calcio | 1:1 (1:0) | ||
| 17:30 | Calcio Catania | - | AZ Picerno | geannuleerd | ||
| 17:30 | Fidelis Andria | - | US Catanzaro | 0:1 (0:1) | ||
| 17:30 | Paganese Calcio | - | Campobasso | 2:1 (1:1) | ||
| 17:30 | Palermo FC | - | Juve Stabia | 3:1 (2:0) | ||
| 17:30 | Potenza | - | Vibonese Calcio | 4:2 (1:0) | ||
| 17:30 | SS Monopoli 1966 | - | SSC Bari | 0:0 (0:0) | ||
| 17:30 | US Avellino | - | Monterosi FC | 2:0 (1:0) | ||
| 21:00 | Taranto FC | - | Virtus Francavilla | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 24 | 15 | 6 | 3 | 39:17 | 22 | 51 |
| 2 |
|
Virtus Francavilla | 25 | 14 | 4 | 7 | 35:19 | 16 | 46 |
| 3 |
|
Palermo FC | 25 | 12 | 9 | 4 | 39:21 | 18 | 45 |
| 4 |
|
US Avellino | 25 | 11 | 12 | 2 | 33:18 | 15 | 45 |
| 5 |
|
US Catanzaro | 24 | 11 | 9 | 4 | 31:14 | 17 | 42 |
| 6 |
|
FC Turris | 24 | 12 | 3 | 9 | 41:27 | 14 | 39 |
| 7 |
|
SS Monopoli 1966 | 24 | 10 | 7 | 7 | 25:22 | 3 | 37 |
| 8 |
|
Juve Stabia | 25 | 9 | 9 | 7 | 30:28 | 2 | 34 |
| 9 |
|
Latina Calcio | 25 | 9 | 6 | 10 | 29:29 | 0 | 33 |
| 10 |
|
AZ Picerno | 24 | 9 | 6 | 9 | 25:27 | -2 | 33 |
| 11 |
|
Foggia Calcio | 25 | 7 | 11 | 7 | 35:33 | 2 | 32 |
| 12 |
|
Taranto FC | 25 | 7 | 10 | 8 | 25:29 | -4 | 31 |
| 13 |
|
Monterosi FC | 25 | 7 | 9 | 9 | 25:33 | -8 | 30 |
| 14 |
|
Campobasso | 25 | 6 | 8 | 11 | 27:40 | -13 | 26 |
| 15 |
|
ACR Messina | 25 | 6 | 7 | 12 | 28:44 | -16 | 25 |
| 16 |
|
Paganese Calcio | 24 | 6 | 5 | 13 | 25:40 | -15 | 23 |
| 17 |
|
Potenza | 25 | 5 | 7 | 13 | 23:39 | -16 | 22 |
| 18 |
|
Fidelis Andria | 24 | 4 | 6 | 14 | 18:34 | -16 | 18 |
| 19 |
|
Vibonese Calcio | 25 | 2 | 10 | 13 | 17:36 | -19 | 16 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
