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| U | Club San Luis | - | Cruz Azul | 0:1 (0:1) | ||
| R | Cruz Azul | - | Club San Luis | 1:1 (0:1) | ||
| U: 22.05.2008 03:00 | R: 25.05.2008 00:00 | Winnaars: Cruz Azul | ||||
| U | CF Monterrey | - | Santos Laguna | 1:1 (1:0) | ||
| R | Santos Laguna | - | CF Monterrey | 2:2 (0:0) | ||
| U: 23.05.2008 03:00 | R: 26.05.2008 00:00 | Winnaars: CF Monterrey | ||||
