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| 01.09.2022 | 20:00 | Telstar | - | De Graafschap | 0:1 (0:0) | |
| 02.09.2022 | 20:00 | FC Den Bosch | - | PEC Zwolle | 1:2 (1:1) | |
| 20:00 | Helmond Sport | - | Almere City FC | 3:0 (1:0) | ||
| 20:00 | NAC Breda | - | FC Eindhoven | 1:1 (1:1) | ||
| 20:00 | VVV-Venlo | - | Jong FC Utrecht | 2:1 (1:0) | ||
| 20:00 | Willem II | - | ADO Den Haag | 1:0 (0:0) | ||
| 04.09.2022 | 12:15 | MVV Maastricht | - | Roda JC Kerkrade | 1:1 (1:0) | |
| 05.09.2022 | 20:00 | Jong Ajax | - | Heracles Almelo | 4:0 (1:0) | |
| 20:00 | Jong AZ Alkmaar | - | FC Dordrecht | 3:1 (0:1) | ||
| 20:00 | Jong PSV | - | TOP Oss | 0:3 (0:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
PEC Zwolle | 5 | 5 | 0 | 0 | 17:4 | 13 | 15 |
| 2 |
|
FC Eindhoven | 5 | 4 | 1 | 0 | 8:3 | 5 | 13 |
| 3 |
|
Jong AZ Alkmaar | 5 | 4 | 0 | 1 | 12:6 | 6 | 12 |
| 4 |
|
VVV-Venlo | 5 | 4 | 0 | 1 | 9:7 | 2 | 12 |
| 5 |
|
Heracles Almelo | 5 | 3 | 1 | 1 | 12:6 | 6 | 10 |
| 6 |
|
NAC Breda | 5 | 3 | 1 | 1 | 7:5 | 2 | 10 |
| 7 |
|
Roda JC Kerkrade | 5 | 3 | 1 | 1 | 8:4 | 4 | 10 |
| 8 |
|
MVV Maastricht | 5 | 2 | 2 | 1 | 10:8 | 2 | 8 |
| 9 |
|
Willem II | 5 | 2 | 2 | 1 | 5:4 | 1 | 8 |
| 10 |
|
Jong Ajax | 5 | 2 | 1 | 2 | 10:7 | 3 | 7 |
| 11 |
|
TOP Oss | 5 | 2 | 0 | 3 | 7:6 | 1 | 6 |
| 12 |
|
Almere City FC | 5 | 2 | 0 | 3 | 7:9 | -2 | 6 |
| 13 |
|
FC Dordrecht | 5 | 1 | 1 | 3 | 4:8 | -4 | 4 |
| 14 |
|
De Graafschap | 5 | 1 | 1 | 3 | 5:10 | -5 | 4 |
| 15 |
|
Telstar | 5 | 1 | 1 | 3 | 4:10 | -6 | 4 |
| 16 |
|
Jong PSV | 5 | 1 | 1 | 3 | 4:11 | -7 | 4 |
| 17 |
|
ADO Den Haag | 5 | 1 | 0 | 4 | 5:10 | -5 | 3 |
| 18 |
|
FC Den Bosch | 5 | 1 | 0 | 4 | 4:10 | -6 | 3 |
| 19 |
|
Helmond Sport | 5 | 1 | 0 | 4 | 5:7 | -2 | 3 |
| 20 |
|
Jong FC Utrecht | 5 | 0 | 1 | 4 | 2:10 | -8 | 1 |
| Promotie | |
| Play-offs |
