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| 09.09.2022 | 20:00 | ADO Den Haag | - | Jong AZ Alkmaar | 2:2 (1:0) | |
| 20:00 | Almere City FC | - | Telstar | 0:1 (0:0) | ||
| 20:00 | FC Dordrecht | - | FC Den Bosch | 2:1 (1:0) | ||
| 20:00 | FC Eindhoven | - | MVV Maastricht | 5:0 (2:0) | ||
| 20:00 | De Graafschap | - | NAC Breda | 1:1 (0:1) | ||
| 20:00 | Heracles Almelo | - | VVV-Venlo | 5:3 (2:1) | ||
| 20:00 | TOP Oss | - | Jong Ajax | 1:1 (0:1) | ||
| 20:00 | PEC Zwolle | - | Willem II | 2:2 (2:2) | ||
| 20:00 | Roda JC Kerkrade | - | Jong PSV | 1:1 (0:0) | ||
| 20:00 | Jong FC Utrecht | - | Helmond Sport | 2:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
PEC Zwolle | 6 | 5 | 1 | 0 | 19:6 | 13 | 16 |
| 2 |
|
FC Eindhoven | 6 | 5 | 1 | 0 | 13:3 | 10 | 16 |
| 3 |
|
Heracles Almelo | 6 | 4 | 1 | 1 | 17:9 | 8 | 13 |
| 4 |
|
Jong AZ Alkmaar | 6 | 4 | 1 | 1 | 14:8 | 6 | 13 |
| 5 |
|
VVV-Venlo | 6 | 4 | 0 | 2 | 12:12 | 0 | 12 |
| 6 |
|
NAC Breda | 6 | 3 | 2 | 1 | 8:6 | 2 | 11 |
| 7 |
|
Roda JC Kerkrade | 6 | 3 | 2 | 1 | 9:5 | 4 | 11 |
| 8 |
|
Willem II | 6 | 2 | 3 | 1 | 7:6 | 1 | 9 |
| 9 |
|
Jong Ajax | 6 | 2 | 2 | 2 | 11:8 | 3 | 8 |
| 10 |
|
MVV Maastricht | 6 | 2 | 2 | 2 | 10:13 | -3 | 8 |
| 11 |
|
TOP Oss | 6 | 2 | 1 | 3 | 8:7 | 1 | 7 |
| 12 |
|
FC Dordrecht | 6 | 2 | 1 | 3 | 6:9 | -3 | 7 |
| 13 |
|
Telstar | 6 | 2 | 1 | 3 | 5:10 | -5 | 7 |
| 14 |
|
Almere City FC | 6 | 2 | 0 | 4 | 7:10 | -3 | 6 |
| 15 |
|
De Graafschap | 6 | 1 | 2 | 3 | 6:11 | -5 | 5 |
| 16 |
|
Jong PSV | 6 | 1 | 2 | 3 | 5:12 | -7 | 5 |
| 17 |
|
ADO Den Haag | 6 | 1 | 1 | 4 | 7:12 | -5 | 4 |
| 18 |
|
Jong FC Utrecht | 6 | 1 | 1 | 4 | 4:10 | -6 | 4 |
| 19 |
|
FC Den Bosch | 6 | 1 | 0 | 5 | 5:12 | -7 | 3 |
| 20 |
|
Helmond Sport | 6 | 1 | 0 | 5 | 5:9 | -4 | 3 |
| Promotie | |
| Play-offs |
