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| 16.09.2022 | 20:00 | FC Eindhoven | - | Roda JC Kerkrade | 3:3 (2:0) | |
| 20:00 | De Graafschap | - | Almere City FC | 1:2 (1:0) | ||
| 20:00 | Helmond Sport | - | FC Dordrecht | 2:1 (0:1) | ||
| 20:00 | MVV Maastricht | - | Jong Ajax | 4:1 (2:0) | ||
| 20:00 | NAC Breda | - | Jong FC Utrecht | 3:1 (1:1) | ||
| 20:00 | PEC Zwolle | - | ADO Den Haag | 1:2 (1:1) | ||
| 20:00 | Telstar | - | Heracles Almelo | 0:3 (0:0) | ||
| 20:00 | VVV-Venlo | - | Jong PSV | 1:1 (1:0) | ||
| 20:00 | Willem II | - | Jong AZ Alkmaar | 1:0 (0:0) | ||
| 17.09.2022 | 16:30 | FC Den Bosch | - | TOP Oss | 4:1 (2:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Eindhoven | 7 | 5 | 2 | 0 | 16:6 | 10 | 17 |
| 2 |
|
PEC Zwolle | 7 | 5 | 1 | 1 | 20:8 | 12 | 16 |
| 3 |
|
Heracles Almelo | 7 | 5 | 1 | 1 | 20:9 | 11 | 16 |
| 4 |
|
NAC Breda | 7 | 4 | 2 | 1 | 11:7 | 4 | 14 |
| 5 |
|
Jong AZ Alkmaar | 7 | 4 | 1 | 2 | 14:9 | 5 | 13 |
| 6 |
|
VVV-Venlo | 7 | 4 | 1 | 2 | 13:13 | 0 | 13 |
| 7 |
|
Willem II | 7 | 3 | 3 | 1 | 8:6 | 2 | 12 |
| 8 |
|
Roda JC Kerkrade | 7 | 3 | 3 | 1 | 12:8 | 4 | 12 |
| 9 |
|
MVV Maastricht | 7 | 3 | 2 | 2 | 14:14 | 0 | 11 |
| 10 |
|
Almere City FC | 7 | 3 | 0 | 4 | 9:11 | -2 | 9 |
| 11 |
|
Jong Ajax | 7 | 2 | 2 | 3 | 12:12 | 0 | 8 |
| 12 |
|
TOP Oss | 7 | 2 | 1 | 4 | 9:11 | -2 | 7 |
| 13 |
|
ADO Den Haag | 7 | 2 | 1 | 4 | 9:13 | -4 | 7 |
| 14 |
|
FC Dordrecht | 7 | 2 | 1 | 4 | 7:11 | -4 | 7 |
| 15 |
|
Telstar | 7 | 2 | 1 | 4 | 5:13 | -8 | 7 |
| 16 |
|
FC Den Bosch | 7 | 2 | 0 | 5 | 9:13 | -4 | 6 |
| 17 |
|
Jong PSV | 7 | 1 | 3 | 3 | 6:13 | -7 | 6 |
| 18 |
|
Helmond Sport | 7 | 2 | 0 | 5 | 7:10 | -3 | 6 |
| 19 |
|
De Graafschap | 7 | 1 | 2 | 4 | 7:13 | -6 | 5 |
| 20 |
|
Jong FC Utrecht | 7 | 1 | 1 | 5 | 5:13 | -8 | 4 |
| Promotie | |
| Play-offs |
