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| 12.09.2022 | 20:00 | Jong Ajax | - | NAC Breda | 3:1 (0:1) | |
| 20:00 | Almere City FC | - | FC Eindhoven | 1:1 (0:0) | ||
| 20:00 | Jong AZ Alkmaar | - | PEC Zwolle | 2:3 (1:1) | ||
| 20:00 | Jong PSV | - | FC Den Bosch | 3:1 (1:0) | ||
| 20:00 | Roda JC Kerkrade | - | De Graafschap | 3:2 (2:0) | ||
| 20:00 | Jong FC Utrecht | - | ADO Den Haag | 1:1 (0:0) | ||
| 23.09.2022 | 21:00 | FC Dordrecht | - | MVV Maastricht | 1:2 (1:1) | |
| 21:00 | Heracles Almelo | - | Helmond Sport | 2:0 (0:0) | ||
| 21:00 | TOP Oss | - | Willem II | 1:3 (0:3) | ||
| 21:00 | VVV-Venlo | - | Telstar | 1:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
PEC Zwolle | 8 | 6 | 1 | 1 | 23:10 | 13 | 19 |
| 2 |
|
Heracles Almelo | 8 | 6 | 1 | 1 | 22:9 | 13 | 19 |
| 3 |
|
FC Eindhoven | 8 | 5 | 3 | 0 | 17:7 | 10 | 18 |
| 4 |
|
Willem II | 8 | 4 | 3 | 1 | 11:7 | 4 | 15 |
| 5 |
|
Roda JC Kerkrade | 8 | 4 | 3 | 1 | 15:10 | 5 | 15 |
| 6 |
|
NAC Breda | 8 | 4 | 2 | 2 | 12:10 | 2 | 14 |
| 7 |
|
MVV Maastricht | 8 | 4 | 2 | 2 | 16:15 | 1 | 14 |
| 8 |
|
VVV-Venlo | 8 | 4 | 2 | 2 | 14:14 | 0 | 14 |
| 9 |
|
Jong AZ Alkmaar | 8 | 4 | 1 | 3 | 16:12 | 4 | 13 |
| 10 |
|
Jong Ajax | 8 | 3 | 2 | 3 | 15:13 | 2 | 11 |
| 11 |
|
Almere City FC | 8 | 3 | 1 | 4 | 10:12 | -2 | 10 |
| 12 |
|
Jong PSV | 8 | 2 | 3 | 3 | 9:14 | -5 | 9 |
| 13 |
|
ADO Den Haag | 8 | 2 | 2 | 4 | 10:14 | -4 | 8 |
| 14 |
|
Telstar | 8 | 2 | 2 | 4 | 6:14 | -8 | 8 |
| 15 |
|
TOP Oss | 8 | 2 | 1 | 5 | 10:14 | -4 | 7 |
| 16 |
|
FC Dordrecht | 8 | 2 | 1 | 5 | 8:13 | -5 | 7 |
| 17 |
|
FC Den Bosch | 8 | 2 | 0 | 6 | 10:16 | -6 | 6 |
| 18 |
|
Helmond Sport | 8 | 2 | 0 | 6 | 7:12 | -5 | 6 |
| 19 |
|
De Graafschap | 8 | 1 | 2 | 5 | 9:16 | -7 | 5 |
| 20 |
|
Jong FC Utrecht | 8 | 1 | 2 | 5 | 6:14 | -8 | 5 |
| Promotie | |
| Play-offs |
