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| 30.09.2022 | 20:00 | ADO Den Haag | - | Jong PSV | 1:3 (0:3) | |
| 20:00 | Almere City FC | - | Roda JC Kerkrade | 2:1 (1:1) | ||
| 20:00 | FC Den Bosch | - | Heracles Almelo | 1:2 (1:1) | ||
| 20:00 | FC Eindhoven | - | FC Dordrecht | 1:1 (0:0) | ||
| 20:00 | De Graafschap | - | Jong AZ Alkmaar | 2:0 (1:0) | ||
| 20:00 | Helmond Sport | - | TOP Oss | 1:2 (1:2) | ||
| 20:00 | MVV Maastricht | - | Willem II | 3:2 (0:2) | ||
| 20:00 | NAC Breda | - | VVV-Venlo | 1:2 (0:0) | ||
| 20:00 | PEC Zwolle | - | Jong Ajax | 1:1 (0:0) | ||
| 20:00 | Telstar | - | Jong FC Utrecht | 2:2 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Heracles Almelo | 9 | 7 | 1 | 1 | 24:10 | 14 | 22 |
| 2 |
|
PEC Zwolle | 9 | 6 | 2 | 1 | 24:11 | 13 | 20 |
| 3 |
|
FC Eindhoven | 9 | 5 | 4 | 0 | 18:8 | 10 | 19 |
| 4 |
|
MVV Maastricht | 9 | 5 | 2 | 2 | 19:17 | 2 | 17 |
| 5 |
|
VVV-Venlo | 9 | 5 | 2 | 2 | 16:15 | 1 | 17 |
| 6 |
|
Willem II | 9 | 4 | 3 | 2 | 13:10 | 3 | 15 |
| 7 |
|
Roda JC Kerkrade | 9 | 4 | 3 | 2 | 16:12 | 4 | 15 |
| 8 |
|
NAC Breda | 9 | 4 | 2 | 3 | 13:12 | 1 | 14 |
| 9 |
|
Jong AZ Alkmaar | 9 | 4 | 1 | 4 | 16:14 | 2 | 13 |
| 10 |
|
Almere City FC | 9 | 4 | 1 | 4 | 12:13 | -1 | 13 |
| 11 |
|
Jong Ajax | 9 | 3 | 3 | 3 | 16:14 | 2 | 12 |
| 12 |
|
Jong PSV | 9 | 3 | 3 | 3 | 12:15 | -3 | 12 |
| 13 |
|
TOP Oss | 9 | 3 | 1 | 5 | 12:15 | -3 | 10 |
| 14 |
|
Telstar | 9 | 2 | 3 | 4 | 8:16 | -8 | 9 |
| 15 |
|
De Graafschap | 9 | 2 | 2 | 5 | 11:16 | -5 | 8 |
| 16 |
|
FC Dordrecht | 9 | 2 | 2 | 5 | 9:14 | -5 | 8 |
| 17 |
|
ADO Den Haag | 9 | 2 | 2 | 5 | 11:17 | -6 | 8 |
| 18 |
|
FC Den Bosch | 9 | 2 | 0 | 7 | 11:18 | -7 | 6 |
| 19 |
|
Jong FC Utrecht | 9 | 1 | 3 | 5 | 8:16 | -8 | 6 |
| 20 |
|
Helmond Sport | 9 | 2 | 0 | 7 | 8:14 | -6 | 6 |
| Promotie | |
| Play-offs |
