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| 01.10.2022 | 16:30 | SC Cambuur | - | PSV | 3:0 (0:0) | |
| 18:45 | FC Groningen | - | AZ Alkmaar | 1:4 (1:2) | ||
| 20:00 | AFC Ajax | - | Go Ahead Eagles | 1:1 (1:0) | ||
| 21:00 | FC Twente | - | Vitesse | 3:0 (1:0) | ||
| 02.10.2022 | 12:15 | Fortuna Sittard | - | FC Volendam | 2:0 (2:0) | |
| 14:30 | SBV Excelsior | - | FC Utrecht | 0:1 (0:1) | ||
| 14:30 | NEC Nijmegen | - | Feyenoord | 1:1 (1:1) | ||
| 16:45 | RKC Waalwijk | - | Sparta Rotterdam | 2:2 (1:1) | ||
| 20:00 | FC Emmen | - | sc Heerenveen | 0:0 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AZ Alkmaar | 8 | 6 | 2 | 0 | 17:6 | 11 | 20 |
| 2 |
|
AFC Ajax | 8 | 6 | 1 | 1 | 23:6 | 17 | 19 |
| 3 |
|
PSV | 8 | 6 | 0 | 2 | 28:13 | 15 | 18 |
| 4 |
|
Feyenoord | 8 | 5 | 2 | 1 | 21:10 | 11 | 17 |
| 5 |
|
FC Twente | 8 | 5 | 1 | 2 | 15:5 | 10 | 16 |
| 6 |
|
sc Heerenveen | 8 | 3 | 4 | 1 | 8:7 | 1 | 13 |
| 7 |
|
FC Utrecht | 8 | 3 | 3 | 2 | 10:10 | 0 | 12 |
| 8 |
|
Sparta Rotterdam | 8 | 3 | 2 | 3 | 11:10 | 1 | 11 |
| 9 |
|
RKC Waalwijk | 8 | 2 | 4 | 2 | 17:12 | 5 | 10 |
| 10 |
|
NEC Nijmegen | 8 | 1 | 6 | 1 | 8:6 | 2 | 9 |
| 11 |
|
SBV Excelsior | 8 | 3 | 0 | 5 | 10:19 | -9 | 9 |
| 12 |
|
FC Groningen | 8 | 2 | 2 | 4 | 8:16 | -8 | 8 |
| 13 |
|
Go Ahead Eagles | 8 | 2 | 1 | 5 | 11:16 | -5 | 7 |
| 14 |
|
Fortuna Sittard | 8 | 2 | 1 | 5 | 11:17 | -6 | 7 |
| 15 |
|
SC Cambuur | 8 | 2 | 1 | 5 | 8:14 | -6 | 7 |
| 16 |
|
Vitesse | 8 | 1 | 2 | 5 | 7:19 | -12 | 5 |
| 17 |
|
FC Emmen | 8 | 1 | 2 | 5 | 6:18 | -12 | 5 |
| 18 |
|
FC Volendam | 8 | 1 | 2 | 5 | 8:23 | -15 | 5 |
| Champions League | |
| Champions League Kwali. | |
| Europa League Kwali. | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
