| 18. Ronde | 20.02.2022 | Etzella Ettelbruck | - | Swift Hesperange | 0:2 |  |
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| 19. Ronde | 27.02.2022 | Swift Hesperange | - | FC Differdange 03 | 3:0 | |
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| 20. Ronde | 06.03.2022 | Victoria Rosport | - | Swift Hesperange | 0:4 | ||||
| 21. Ronde | 13.03.2022 | Swift Hesperange | - | CS FOLA Esch | 1:1 | ||||
| 22. Ronde | 20.03.2022 | UNA Strassen | - | Swift Hesperange | 0:2 | |
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| 23. Ronde | 02.04.2022 | Progrès Niedercorn | - | Swift Hesperange | 2:2 |  |
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| 24. Ronde | 10.04.2022 | Swift Hesperange | - | FC Rodange 91 | 2:0 | ||||
| 25. Ronde | 16.04.2022 | RM Hamm Benfica | - | Swift Hesperange | 0:4 | |
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| 26. Ronde | 24.04.2022 | Swift Hesperange | - | FC Wiltz 71 | 3:2 | ||||
| 27. Ronde | 01.05.2022 | F91 Dudelange | - | Swift Hesperange | 1:0 | ||||
| 29. Ronde | 15.05.2022 | US Hostert | - | Swift Hesperange | 1:3 | |
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| 30. Ronde | 22.05.2022 | Swift Hesperange | - | RFCU Luxemburg | 2:0 |
België