| 3. Ronde | 28.08.2021 | Sporting Gijón | - | CD Mirandés | 2:1 | ||||
| 4. Ronde | 03.09.2021 | Girona FC | - | Sporting Gijón | 1:2 | ||||
| 5. Ronde | 10.09.2021 | Sporting Gijón | - | CD Leganés | 2:1 | ||||
| 6. Ronde | 19.09.2021 | SD Eibar | - | Sporting Gijón | 3:2 | ||||
| 7. Ronde | 26.09.2021 | Sporting Gijón | - | Málaga CF | 2:1 | ||||
| 8. Ronde | 02.10.2021 | SD Amorebieta | - | Sporting Gijón | 1:1 | ||||
| 9. Ronde | 09.10.2021 | Real Oviedo | - | Sporting Gijón | 1:1 | ||||
| 15. Ronde | 07.11.2021 | Real Zaragoza | - | Sporting Gijón | 2:0 | ||||
| 24. Ronde | 23.01.2022 | Sporting Gijón | - | SD Amorebieta | 2:1 | ||||
| 25. Ronde | 28.01.2022 | Real Valladolid | - | Sporting Gijón | 1:0 | ||||
| 26. Ronde | 05.02.2022 | Sporting Gijón | - | SD Eibar | 0:1 | ||||
| 29. Ronde | 27.02.2022 | Sporting Gijón | - | Real Zaragoza | 1:2 | ||||
| 35. Ronde | 09.04.2022 | AD Alcorcón | - | Sporting Gijón | 1:1 |  |
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| 36. Ronde | 16.04.2022 | Sporting Gijón | - | Real Oviedo | 0:1 | ||||
| 37. Ronde | 25.04.2022 | UD Almería | - | Sporting Gijón | 1:0 | ||||
| 38. Ronde | 01.05.2022 | Sporting Gijón | - | UD Ibiza | 0:1 | ||||
| 39. Ronde | 07.05.2022 | SD Huesca | - | Sporting Gijón | 1:1 | ||||
| 42. Ronde | 29.05.2022 | Sporting Gijón | - | UD Las Palmas | 0:1 |
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