| 2. Ronde | 12.09.2021 | Delfino Pescara [A-jun] | - | Empoli FC [A-jun] | 0:0 | ||||
| 3. Ronde | 18.09.2021 | Empoli FC [A-jun] | - | SPAL 2013 Ferrara [A-jun] | 6:0 |  |
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| 4. Ronde | 25.09.2021 | Torino FC [A-jun] | - | Empoli FC [A-jun] | 1:2 | ||||
| 5. Ronde | 16.10.2021 | Empoli FC [A-jun] | - | Inter [A-jun] | 1:1 | ||||
| 6. Ronde | 24.10.2021 | AS Roma [A-jun] | - | Empoli FC [A-jun] | 2:2 | ||||
| 7. Ronde | 31.10.2021 | Empoli FC [A-jun] | - | SSC Napoli [A-jun] | 1:0 | ||||
| 8. Ronde | 07.11.2021 | US Lecce [A-jun] | - | Empoli FC [A-jun] | 0:0 | ||||
| 9. Ronde | 20.11.2021 | Empoli FC [A-jun] | - | ACF Fiorentina [A-jun] | 2:0 | |
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| 10. Ronde | 28.11.2021 | Sampdoria [A-jun] | - | Empoli FC [A-jun] | 2:0 | ||||
| 11. Ronde | 05.12.2021 | Empoli FC [A-jun] | - | Atalanta [A-jun] | 1:1 | ||||
| 12. Ronde | 13.12.2021 | Bologna FC [A-jun] | - | Empoli FC [A-jun] | 3:0 | ||||
| 13. Ronde | 17.12.2021 | Empoli FC [A-jun] | - | Juventus [A-jun] | 1:2 | ||||
| 14. Ronde | 21.12.2021 | Empoli FC [A-jun] | - | Sassuolo Calcio [A-jun] | 0:2 | ||||
| 16. Ronde | 01.02.2022 | Empoli FC [A-jun] | - | Genoa CFC [A-jun] | 0:1 | ||||
| 17. Ronde | 04.02.2022 | Cagliari Calcio [A-jun] | - | Empoli FC [A-jun] | 2:0 |
Italië