| 7. Ronde | 02.10.2021 | FC Crotone | - | Ascoli Calcio | 2:2 | ||||
| 8. Ronde | 16.10.2021 | FC Crotone | - | Pisa SC | 2:1 | ||||
| 9. Ronde | 22.10.2021 | US Alessandria 1912 | - | FC Crotone | 1:0 |  |
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| 10. Ronde | 28.10.2021 | FC Crotone | - | Benevento Calcio | 0:2 | ||||
| 14. Ronde | 26.11.2021 | FC Crotone | - | L.R. Vicenza | 0:1 | ||||
| 18. Ronde | 18.12.2021 | FC Crotone | - | Pordenone Calcio | 4:1 | ||||
| 20. Ronde | 22.01.2022 | Como 1907 | - | FC Crotone | 1:1 | ||||
| 19. Ronde | 30.01.2022 | Parma Calcio 1913 | - | FC Crotone | 1:1 | ||||
| 21. Ronde | 05.02.2022 | FC Crotone | - | AS Cittadella | 0:0 | ||||
| 22. Ronde | 12.02.2022 | Reggina 1914 | - | FC Crotone | 1:0 | ||||
| 23. Ronde | 16.02.2022 | FC Crotone | - | Brescia Calcio | 0:1 | ||||
| 24. Ronde | 20.02.2022 | US Lecce | - | FC Crotone | 3:0 |  |
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| 26. Ronde | 27.02.2022 | Ascoli Calcio | - | FC Crotone | 2:1 | ||||
| 27. Ronde | 02.03.2022 | Pisa SC | - | FC Crotone | 3:2 |  |
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| 30. Ronde | 15.03.2022 | FC Crotone | - | Frosinone Calcio | 2:0 | ||||
| 35. Ronde | 18.04.2022 | SPAL 2013 Ferrara | - | FC Crotone | 1:1 | ||||
| 36. Ronde | 25.04.2022 | FC Crotone | - | US Cremonese | 3:1 | |
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| 37. Ronde | 30.04.2022 | Pordenone Calcio | - | FC Crotone | 3:3 | ||||
| 38. Ronde | 06.05.2022 | FC Crotone | - | Parma Calcio 1913 | 0:1 |
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