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| 13.04.2022 | 14:00 | Boca Juniors II | - | Lanús II | 1:3 (0:2) | |
| 15:00 | Godoy Cruz II | - | Vélez Sarsfield II | 1:0 (1:0) | ||
| 15:00 | Barracas Central II | - | Estudiantes II | 2:2 (0:1) | ||
| 16:00 | Newell's Old Boys II | - | Patronato de Paraná II | 1:0 (0:0) | ||
| 16:00 | Central Córdoba SdE II | - | Arsenal de Sarandí II | 2:0 (0:0) | ||
| 16:00 | Tigre II | - | Huracán II | 1:3 (0:1) | ||
| 16:00 | Colón de Santa Fe II | - | Independiente II | 0:1 (0:1) | ||
| 14.04.2022 | 14:00 | Banfield II | - | River Plate II | 2:3 (2:1) | |
| 14:00 | Argentinos Juniors II | - | Talleres de Córdoba II | 5:0 (3:0) | ||
| 16:00 | Aldosivi II | - | Rosario Central II | 1:0 (0:0) | ||
| 15.04.2022 | 14:00 | San Lorenzo II | - | Platense II | 1:1 (0:1) | |
| 14:00 | Racing Club II | - | Unión de Santa Fe II | 2:0 (1:0) | ||
| 15:00 | Gimnasia de La Plata II | - | Sarmiento de Junín II | 1:0 (0:0) | ||
| 16:00 | Defensa y Justicia II | - | Atlético Tucumán II | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Defensa y Justicia II | 10 | 8 | 0 | 2 | 16:7 | 9 | 24 |
| 2 |
|
Banfield II | 10 | 7 | 2 | 1 | 18:10 | 8 | 23 |
| 3 |
|
Gimnasia de La Plata II | 10 | 7 | 0 | 3 | 21:15 | 6 | 21 |
| 4 |
|
River Plate II | 10 | 5 | 3 | 2 | 16:11 | 5 | 18 |
| 5 |
|
Argentinos Juniors II | 10 | 4 | 3 | 3 | 16:7 | 9 | 15 |
| 6 |
|
Sarmiento de Junín II | 10 | 4 | 2 | 4 | 12:10 | 2 | 14 |
| 7 |
|
Atlético Tucumán II | 10 | 4 | 2 | 4 | 19:19 | 0 | 14 |
| 8 |
|
Talleres de Córdoba II | 10 | 3 | 3 | 4 | 22:17 | 5 | 12 |
| 9 |
|
Newell's Old Boys II | 10 | 3 | 3 | 4 | 14:14 | 0 | 12 |
| 10 |
|
Platense II | 10 | 3 | 3 | 4 | 13:15 | -2 | 12 |
| 11 |
|
Unión de Santa Fe II | 10 | 2 | 4 | 4 | 5:16 | -11 | 10 |
| 12 |
|
San Lorenzo II | 10 | 2 | 3 | 5 | 9:19 | -10 | 9 |
| 13 |
|
Racing Club II | 10 | 2 | 1 | 7 | 13:20 | -7 | 7 |
| 14 |
|
Patronato de Paraná II | 10 | 1 | 2 | 7 | 6:14 | -8 | 5 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Central Córdoba SdE II | 10 | 6 | 3 | 1 | 15:7 | 8 | 21 |
| 2 |
|
Tigre II | 10 | 5 | 3 | 2 | 17:10 | 7 | 18 |
| 3 |
|
Lanús II | 10 | 5 | 3 | 2 | 17:13 | 4 | 18 |
| 4 |
|
Rosario Central II | 10 | 5 | 2 | 3 | 19:10 | 9 | 17 |
| 5 |
|
Aldosivi II | 10 | 5 | 1 | 4 | 14:10 | 4 | 16 |
| 6 |
|
Estudiantes II | 10 | 4 | 3 | 3 | 16:15 | 1 | 15 |
| 7 |
|
Huracán II | 10 | 4 | 2 | 4 | 18:10 | 8 | 14 |
| 8 |
|
Boca Juniors II | 10 | 3 | 5 | 2 | 12:11 | 1 | 14 |
| 9 |
|
Arsenal de Sarandí II | 10 | 4 | 2 | 4 | 10:13 | -3 | 14 |
| 10 |
|
Independiente II | 10 | 3 | 4 | 3 | 11:10 | 1 | 13 |
| 11 |
|
Colón de Santa Fe II | 10 | 3 | 1 | 6 | 7:12 | -5 | 10 |
| 12 |
|
Barracas Central II | 10 | 3 | 1 | 6 | 12:25 | -13 | 10 |
| 13 |
|
Vélez Sarsfield II | 10 | 2 | 3 | 5 | 14:18 | -4 | 9 |
| 14 |
|
Godoy Cruz II | 10 | 1 | 0 | 9 | 5:29 | -24 | 3 |
| Play-offs | |
| Play-offs |
