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| 29.04.2022 | 14:00 | Vélez Sarsfield II | - | Tigre II | 4:2 (2:1) | |
| 14:00 | Boca Juniors II | - | Barracas Central II | 2:0 (0:0) | ||
| 15:00 | Patronato de Paraná II | - | Gimnasia de La Plata II | 2:2 (1:1) | ||
| 15:00 | Unión de Santa Fe II | - | Defensa y Justicia II | 2:0 (0:0) | ||
| 15:00 | Arsenal de Sarandí II | - | Colón de Santa Fe II | 1:0 (0:0) | ||
| 16:00 | Sarmiento de Junín II | - | River Plate II | 1:2 (0:2) | ||
| 16:00 | Lanús II | - | Independiente II | 1:2 (0:1) | ||
| 16:00 | Huracán II | - | Rosario Central II | 3:0 (1:0) | ||
| 30.04.2022 | 14:00 | Estudiantes II | - | Aldosivi II | 3:1 (3:1) | |
| 16:00 | Newell's Old Boys II | - | San Lorenzo II | 0:3 (0:2) | ||
| 21:00 | Atlético Tucumán II | - | Talleres de Córdoba II | 0:2 (0:1) | ||
| 02.05.2022 | 14:00 | Racing Club II | - | Banfield II | 2:0 (1:0) | |
| 14:00 | Godoy Cruz II | - | Central Córdoba SdE II | 1:0 (1:0) | ||
| 16:00 | Platense II | - | Argentinos Juniors II | 1:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Defensa y Justicia II | 13 | 9 | 1 | 3 | 18:10 | 8 | 28 |
| 2 |
|
River Plate II | 13 | 7 | 4 | 2 | 23:13 | 10 | 25 |
| 3 |
|
Banfield II | 13 | 7 | 3 | 3 | 18:13 | 5 | 24 |
| 4 |
|
Gimnasia de La Plata II | 13 | 7 | 1 | 5 | 24:20 | 4 | 22 |
| 5 |
|
San Lorenzo II | 13 | 5 | 3 | 5 | 19:20 | -1 | 18 |
| 6 |
|
Argentinos Juniors II | 13 | 4 | 5 | 4 | 18:10 | 8 | 17 |
| 7 |
|
Talleres de Córdoba II | 13 | 4 | 5 | 4 | 25:18 | 7 | 17 |
| 8 |
|
Platense II | 13 | 4 | 5 | 4 | 16:17 | -1 | 17 |
| 9 |
|
Atlético Tucumán II | 13 | 5 | 2 | 6 | 21:26 | -5 | 17 |
| 10 |
|
Newell's Old Boys II | 13 | 4 | 4 | 5 | 16:18 | -2 | 16 |
| 11 |
|
Unión de Santa Fe II | 13 | 4 | 4 | 5 | 10:21 | -11 | 16 |
| 12 |
|
Sarmiento de Junín II | 13 | 4 | 3 | 6 | 13:13 | 0 | 15 |
| 13 |
|
Racing Club II | 13 | 3 | 2 | 8 | 17:24 | -7 | 11 |
| 14 |
|
Patronato de Paraná II | 13 | 2 | 3 | 8 | 11:20 | -9 | 9 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes II | 13 | 7 | 3 | 3 | 24:17 | 7 | 24 |
| 2 |
|
Lanús II | 13 | 7 | 3 | 3 | 20:15 | 5 | 24 |
| 3 |
|
Central Córdoba SdE II | 13 | 6 | 4 | 3 | 15:9 | 6 | 22 |
| 4 |
|
Boca Juniors II | 13 | 5 | 6 | 2 | 20:11 | 9 | 21 |
| 5 |
|
Huracán II | 13 | 6 | 2 | 5 | 24:14 | 10 | 20 |
| 6 |
|
Tigre II | 13 | 5 | 4 | 4 | 21:17 | 4 | 19 |
| 7 |
|
Aldosivi II | 13 | 6 | 1 | 6 | 18:16 | 2 | 19 |
| 8 |
|
Independiente II | 13 | 5 | 4 | 4 | 16:14 | 2 | 19 |
| 9 |
|
Arsenal de Sarandí II | 13 | 5 | 4 | 4 | 12:14 | -2 | 19 |
| 10 |
|
Rosario Central II | 13 | 5 | 2 | 6 | 20:16 | 4 | 17 |
| 11 |
|
Vélez Sarsfield II | 13 | 4 | 4 | 5 | 19:20 | -1 | 16 |
| 12 |
|
Colón de Santa Fe II | 13 | 4 | 1 | 8 | 10:17 | -7 | 13 |
| 13 |
|
Barracas Central II | 13 | 3 | 3 | 7 | 12:27 | -15 | 12 |
| 14 |
|
Godoy Cruz II | 13 | 2 | 0 | 11 | 6:36 | -30 | 6 |
| Play-offs | |
| Play-offs |
