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| 01.10.2022 | 02:10 | Gimnasia de Jujuy | - | San Martín de Tucumán | 1:1 (0:1) | |
| 20:10 | Almagro | - | Independiente Rivadavia | 1:0 (0:0) | ||
| 20:20 | Deportivo Madryn | - | Sacachispas | 2:0 (0:0) | ||
| 20:30 | Villa Dálmine | - | Brown de Adrogué | 0:1 (0:0) | ||
| 21:00 | Alvarado | - | Ferro Carril Oeste | 1:1 (0:0) | ||
| 02.10.2022 | 20:30 | Temperley | - | Agropecuario Argentino | 2:0 (1:0) | |
| 20:30 | San Telmo | - | Atlanta | 1:0 (1:0) | ||
| 21:00 | Almirante Brown | - | Defensores de Belgrano | 2:3 (1:1) | ||
| 21:00 | Güemes de SdE | - | Atlético Rafaela | 1:1 (0:0) | ||
| 21:30 | Estudiantes de Río Cuarto | - | Mitre de SdE | 0:0 (0:0) | ||
| 21:30 | Gimnasia de Mendoza | - | Estudiantes de Caseros | 1:0 (1:0) | ||
| 23:00 | Chaco For Ever | - | San Martín de San Juan | 2:1 (1:1) | ||
| 03.10.2022 | 20:05 | Nueva Chicago | - | Quilmes | 2:1 (0:0) | |
| 20:30 | Deportivo Riestra | - | Guillermo Brown | 1:1 (1:1) | ||
| 04.10.2022 | 00:00 | Deportivo Morón | - | Instituto de Córdoba | 1:0 (1:0) | |
| 00:05 | All Boys | - | Ramón Santamarina | 1:0 (1:0) | ||
| 02:00 | Belgrano de Córdoba | - | Chacarita Juniors | 3:0 (1:0) | ||
| 20:00 | Flandria | - | Tristan Suárez | 0:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 35 | 23 | 7 | 5 | 47:23 | 24 | 76 |
| 2 |
|
Instituto de Córdoba | 35 | 18 | 11 | 6 | 45:22 | 23 | 65 |
| 3 |
|
Gimnasia de Mendoza | 35 | 17 | 13 | 5 | 40:16 | 24 | 64 |
| 4 |
|
San Martín de Tucumán | 35 | 16 | 15 | 4 | 42:21 | 21 | 63 |
| 5 |
|
All Boys | 35 | 15 | 15 | 5 | 45:31 | 14 | 60 |
| 6 |
|
Almagro | 35 | 16 | 9 | 10 | 35:31 | 4 | 57 |
| 7 |
|
Chaco For Ever | 36 | 13 | 16 | 7 | 38:28 | 10 | 55 |
| 8 |
|
Estudiantes de Río Cuarto | 35 | 13 | 16 | 6 | 38:29 | 9 | 55 |
| 9 |
|
Defensores de Belgrano | 35 | 13 | 15 | 7 | 36:28 | 8 | 54 |
| 10 |
|
Estudiantes de Caseros | 35 | 15 | 9 | 11 | 31:27 | 4 | 54 |
| 11 |
|
Independiente Rivadavia | 35 | 14 | 11 | 10 | 44:34 | 10 | 53 |
| 12 |
|
Deportivo Morón | 35 | 12 | 16 | 7 | 31:21 | 10 | 52 |
| 13 |
|
Deportivo Riestra | 35 | 11 | 18 | 6 | 32:26 | 6 | 51 |
| 14 |
|
Deportivo Maipú | 35 | 11 | 15 | 9 | 39:31 | 8 | 48 |
| 15 |
|
San Martín de San Juan | 35 | 14 | 6 | 15 | 48:41 | 7 | 48 |
| 16 |
|
Chacarita Juniors | 35 | 12 | 11 | 12 | 48:44 | 4 | 47 |
| 17 |
|
Deportivo Madryn | 35 | 10 | 16 | 9 | 43:39 | 4 | 46 |
| 18 |
|
Mitre de SdE | 35 | 11 | 11 | 13 | 36:37 | -1 | 44 |
| 19 |
|
Ferro Carril Oeste | 35 | 11 | 11 | 13 | 30:34 | -4 | 44 |
| 20 |
|
Brown de Adrogué | 35 | 11 | 10 | 14 | 39:39 | 0 | 43 |
| 21 |
|
Atlanta | 35 | 10 | 13 | 12 | 29:31 | -2 | 43 |
| 22 |
|
Quilmes | 35 | 10 | 13 | 12 | 41:46 | -5 | 43 |
| 23 |
|
Guillermo Brown | 35 | 12 | 7 | 16 | 30:42 | -12 | 43 |
| 24 |
|
Almirante Brown | 35 | 9 | 14 | 12 | 38:43 | -5 | 41 |
| 25 |
|
Temperley | 35 | 9 | 14 | 12 | 33:39 | -6 | 41 |
| 26 |
|
Gimnasia de Jujuy | 35 | 10 | 11 | 14 | 36:49 | -13 | 41 |
| 27 |
|
Güemes de SdE | 35 | 8 | 15 | 12 | 26:31 | -5 | 39 |
| 28 |
|
San Telmo | 35 | 9 | 12 | 14 | 35:50 | -15 | 39 |
| 29 |
|
Atlético Rafaela | 35 | 8 | 14 | 13 | 40:41 | -1 | 38 |
| 30 |
|
Agropecuario Argentino | 35 | 7 | 16 | 12 | 25:30 | -5 | 37 |
| 31 |
|
Villa Dálmine | 35 | 7 | 16 | 12 | 36:48 | -12 | 37 |
| 32 |
|
Alvarado | 35 | 8 | 12 | 15 | 31:46 | -15 | 36 |
| 33 |
|
Tristan Suárez | 35 | 6 | 14 | 15 | 35:44 | -9 | 32 |
| 34 |
|
Nueva Chicago | 35 | 6 | 14 | 15 | 33:47 | -14 | 32 |
| 35 |
|
Flandria | 35 | 6 | 13 | 16 | 30:46 | -16 | 31 |
| 36 |
|
Sacachispas | 35 | 3 | 18 | 14 | 21:40 | -19 | 27 |
| 37 |
|
Ramón Santamarina | 35 | 5 | 11 | 19 | 25:56 | -31 | 26 |
| Promotie | |
| Play-offs | |
| Play-offs | |
| Degradatie |
