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| 14.06.2022 | 20:00 | San Lorenzo | - | Arsenal de Sarandí | 3:3 (0:1) | |
| 15.06.2022 | 00:00 | Patronato de Paraná | - | Aldosivi | 1:0 (1:0) | |
| 00:00 | Talleres de Córdoba | - | Newell's Old Boys | 0:1 (0:1) | ||
| 02:30 | Defensa y Justicia | - | Huracán | 1:1 (1:1) | ||
| 02:30 | Estudiantes | - | Sarmiento de Junín | 2:1 (1:0) | ||
| 19:00 | Barracas Central | - | Unión de Santa Fe | 1:2 (0:2) | ||
| 21:30 | Atlético Tucumán | - | Lanús | 2:1 (0:1) | ||
| 21:30 | Banfield | - | Central Córdoba SdE | 2:1 (1:0) | ||
| 16.06.2022 | 00:00 | Colón de Santa Fe | - | River Plate | 1:0 (0:0) | |
| 02:30 | Boca Juniors | - | Tigre | 5:3 (1:1) | ||
| 17.06.2022 | 00:00 | Argentinos Juniors | - | Independiente | 2:1 (1:1) | |
| 00:00 | Rosario Central | - | Godoy Cruz | 1:0 (0:0) | ||
| 02:30 | Platense | - | Gimnasia de La Plata | 1:1 (0:0) | ||
| 02:30 | Racing Club | - | Vélez Sarsfield | 2:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 3 | 2 | 1 | 0 | 4:2 | 2 | 7 |
|
Platense | 3 | 2 | 1 | 0 | 4:2 | 2 | 7 | |
| 3 |
|
Newell's Old Boys | 3 | 2 | 1 | 0 | 3:1 | 2 | 7 |
| 4 |
|
Boca Juniors | 3 | 2 | 0 | 1 | 7:5 | 2 | 6 |
| 5 |
|
Racing Club | 3 | 2 | 0 | 1 | 4:2 | 2 | 6 |
| 6 |
|
Argentinos Juniors | 3 | 2 | 0 | 1 | 4:3 | 1 | 6 |
| 7 |
|
Gimnasia de La Plata | 3 | 1 | 2 | 0 | 4:2 | 2 | 5 |
| 8 |
|
Colón de Santa Fe | 3 | 1 | 2 | 0 | 4:3 | 1 | 5 |
| 9 |
|
Atlético Tucumán | 3 | 1 | 2 | 0 | 3:2 | 1 | 5 |
| 10 |
|
Unión de Santa Fe | 3 | 1 | 1 | 1 | 5:5 | 0 | 4 |
| 11 |
|
Banfield | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 |
|
Central Córdoba SdE | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 | |
|
Huracán | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 | |
|
Independiente | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 | |
| 15 |
|
Tigre | 3 | 1 | 1 | 1 | 6:7 | -1 | 4 |
| 16 |
|
Patronato de Paraná | 3 | 1 | 1 | 1 | 2:3 | -1 | 4 |
| 17 |
|
Rosario Central | 3 | 1 | 1 | 1 | 1:2 | -1 | 4 |
| 18 |
|
San Lorenzo | 3 | 0 | 3 | 0 | 4:4 | 0 | 3 |
| 19 |
|
Godoy Cruz | 3 | 1 | 0 | 2 | 3:3 | 0 | 3 |
| 20 |
|
Defensa y Justicia | 3 | 0 | 3 | 0 | 2:2 | 0 | 3 |
|
Talleres de Córdoba | 3 | 1 | 0 | 2 | 2:2 | 0 | 3 | |
| 22 |
|
Sarmiento de Junín | 3 | 1 | 0 | 2 | 2:4 | -2 | 3 |
| 23 |
|
Arsenal de Sarandí | 3 | 0 | 2 | 1 | 4:5 | -1 | 2 |
| 24 |
|
Barracas Central | 3 | 0 | 2 | 1 | 3:4 | -1 | 2 |
| 25 |
|
Lanús | 3 | 0 | 2 | 1 | 2:3 | -1 | 2 |
| 26 |
|
River Plate | 3 | 0 | 2 | 1 | 0:1 | -1 | 2 |
| 27 |
|
Vélez Sarsfield | 3 | 0 | 1 | 2 | 1:4 | -3 | 1 |
| 28 |
|
Aldosivi | 3 | 0 | 0 | 3 | 1:4 | -3 | 0 |
