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| 25.01.2022 | 18:45 | Royal Antwerp FC | - | Sint-Truidense VV | 1:1 (1:0) | |
| 21:00 | KAA Gent | - | KV Oostende | 1:1 (0:1) | ||
| 21:00 | Sporting Charleroi | - | KV Kortrijk | 1:1 (1:1) | ||
| 26.01.2022 | 18:45 | KAS Eupen | - | Standard Luik | 0:2 (0:1) | |
| 18:45 | SV Zulte Waregem | - | Oud-Heverlee Leuven | 1:1 (1:1) | ||
| 21:00 | RSC Anderlecht | - | Cercle Brugge | 0:2 (0:0) | ||
| 21:00 | RFC Seraing | - | K Beerschot VA | 2:1 (1:0) | ||
| 27.01.2022 | 20:45 | Club Brugge KV | - | Union Saint-Gilloise | 0:0 (0:0) | |
| 16.02.2022 | 18:45 | KRC Genk | - | KV Mechelen | 4:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Union Saint-Gilloise | 24 | 17 | 3 | 4 | 56:21 | 35 | 54 |
| 2 |
|
Royal Antwerp FC | 24 | 14 | 5 | 5 | 45:26 | 19 | 47 |
| 3 |
|
Club Brugge KV | 24 | 12 | 9 | 3 | 45:30 | 15 | 45 |
| 4 |
|
RSC Anderlecht | 24 | 11 | 9 | 4 | 52:29 | 23 | 42 |
| 5 |
|
KAA Gent | 24 | 10 | 7 | 7 | 36:25 | 11 | 37 |
| 6 |
|
Sporting Charleroi | 24 | 10 | 7 | 7 | 39:33 | 6 | 37 |
| 7 |
|
KRC Genk | 24 | 10 | 5 | 9 | 49:37 | 12 | 35 |
| 8 |
|
Cercle Brugge | 24 | 10 | 4 | 10 | 35:29 | 6 | 34 |
| 9 |
|
KV Kortrijk | 24 | 8 | 10 | 6 | 30:28 | 2 | 34 |
| 10 |
|
KV Mechelen | 24 | 10 | 3 | 11 | 38:47 | -9 | 33 |
| 11 |
|
Standard Luik | 24 | 8 | 7 | 9 | 28:37 | -9 | 31 |
| 12 |
|
Oud-Heverlee Leuven | 24 | 7 | 9 | 8 | 36:38 | -2 | 30 |
| 13 |
|
Sint-Truidense VV | 24 | 8 | 4 | 12 | 26:35 | -9 | 28 |
| 14 |
|
KAS Eupen | 24 | 7 | 5 | 12 | 31:41 | -10 | 26 |
| 15 |
|
SV Zulte Waregem | 24 | 6 | 7 | 11 | 33:49 | -16 | 25 |
| 16 |
|
KV Oostende | 24 | 7 | 4 | 13 | 25:46 | -21 | 25 |
| 17 |
|
RFC Seraing | 24 | 7 | 1 | 16 | 26:50 | -24 | 22 |
| 18 |
|
K Beerschot VA | 24 | 3 | 3 | 18 | 20:49 | -29 | 12 |
| Play-offs | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
