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| 04.02.2022 | 20:45 | Sporting Charleroi | - | RFC Seraing | 2:0 (1:0) | |
| 05.02.2022 | 16:15 | KV Kortrijk | - | Sint-Truidense VV | 1:3 (0:2) | |
| 18:30 | KV Oostende | - | Oud-Heverlee Leuven | 1:3 (0:1) | ||
| 18:30 | Standard Luik | - | Cercle Brugge | 1:1 (0:1) | ||
| 20:45 | Royal Antwerp FC | - | Union Saint-Gilloise | 0:2 (0:0) | ||
| 06.02.2022 | 13:30 | Club Brugge KV | - | KAA Gent | 1:2 (0:1) | |
| 16:00 | KV Mechelen | - | K Beerschot VA | 3:2 (3:0) | ||
| 18:30 | RSC Anderlecht | - | KAS Eupen | 4:1 (3:1) | ||
| 21:00 | KRC Genk | - | SV Zulte Waregem | 2:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Union Saint-Gilloise | 26 | 19 | 3 | 4 | 59:21 | 38 | 60 |
| 2 |
|
Royal Antwerp FC | 26 | 15 | 5 | 6 | 46:28 | 18 | 50 |
| 3 |
|
Club Brugge KV | 26 | 13 | 9 | 4 | 47:32 | 15 | 48 |
| 4 |
|
RSC Anderlecht | 26 | 12 | 9 | 5 | 56:31 | 25 | 45 |
| 5 |
|
Sporting Charleroi | 26 | 12 | 7 | 7 | 42:33 | 9 | 43 |
| 6 |
|
KAA Gent | 26 | 11 | 7 | 8 | 38:27 | 11 | 40 |
| 7 |
|
KV Mechelen | 26 | 12 | 3 | 11 | 43:50 | -7 | 39 |
| 8 |
|
KRC Genk | 26 | 11 | 5 | 10 | 52:39 | 13 | 38 |
| 9 |
|
Oud-Heverlee Leuven | 26 | 9 | 9 | 8 | 41:40 | 1 | 36 |
| 10 |
|
Cercle Brugge | 26 | 10 | 5 | 11 | 36:31 | 5 | 35 |
| 11 |
|
KV Kortrijk | 26 | 8 | 10 | 8 | 31:32 | -1 | 34 |
| 12 |
|
Standard Luik | 26 | 8 | 8 | 10 | 30:40 | -10 | 32 |
| 13 |
|
Sint-Truidense VV | 26 | 9 | 4 | 13 | 29:37 | -8 | 31 |
| 14 |
|
KV Oostende | 26 | 8 | 4 | 14 | 27:49 | -22 | 28 |
| 15 |
|
KAS Eupen | 26 | 7 | 6 | 13 | 32:45 | -13 | 27 |
| 16 |
|
SV Zulte Waregem | 26 | 6 | 8 | 12 | 36:54 | -18 | 26 |
| 17 |
|
RFC Seraing | 26 | 7 | 2 | 17 | 26:52 | -26 | 23 |
| 18 |
|
K Beerschot VA | 26 | 3 | 4 | 19 | 25:55 | -30 | 13 |
| Play-offs | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
