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| 23.10.2021 | 22:00 | Juventude - RS | - | Ceará - CE | 0:0 (0:0) | |
| 22:00 | Santos FC | - | América - MG | 0:2 (0:1) | ||
| 24.10.2021 | 00:00 | Fluminense RJ | - | Flamengo RJ | 3:1 (1:0) | |
| 00:15 | Fortaleza | - | Athletico Paranaense | 3:0 (2:0) | ||
| 21:00 | Atlético Mineiro | - | Cuiabá - MT | 2:1 (2:1) | ||
| 21:00 | Internacional | - | Corinthians SP | 2:2 (1:0) | ||
| 23:15 | Red Bull Bragantino | - | São Paulo FC | 1:0 (0:0) | ||
| 25.10.2021 | 01:30 | Bahia - BA | - | Chapecoense | 3:0 (2:0) | |
| 26.10.2021 | 01:00 | Atlético Goianiense | - | Grêmio Porto Alegre | 2:0 (1:0) | |
| 02:30 | Palmeiras | - | Sport Recife - PE | 2:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Mineiro | 28 | 19 | 5 | 4 | 46:21 | 25 | 62 |
| 2 |
|
Flamengo RJ | 28 | 15 | 6 | 7 | 53:28 | 25 | 51 |
| 3 |
|
Palmeiras | 28 | 15 | 4 | 9 | 42:34 | 8 | 49 |
| 4 |
|
Fortaleza | 28 | 14 | 6 | 8 | 38:30 | 8 | 48 |
| 5 |
|
Red Bull Bragantino | 28 | 11 | 13 | 4 | 44:32 | 12 | 46 |
| 6 |
|
Internacional | 28 | 10 | 11 | 7 | 37:30 | 7 | 41 |
| 7 |
|
Corinthians SP | 28 | 10 | 11 | 7 | 30:26 | 4 | 41 |
| 8 |
|
Fluminense RJ | 28 | 10 | 9 | 9 | 28:30 | -2 | 39 |
| 9 |
|
Atlético Goianiense | 28 | 9 | 10 | 9 | 24:26 | -2 | 37 |
| 10 |
|
Athletico Paranaense | 28 | 10 | 5 | 13 | 34:38 | -4 | 35 |
| 11 |
|
América - MG | 28 | 8 | 11 | 9 | 27:29 | -2 | 35 |
| 12 |
|
Cuiabá - MT | 28 | 7 | 14 | 7 | 27:28 | -1 | 35 |
| 13 |
|
São Paulo FC | 28 | 7 | 13 | 8 | 22:27 | -5 | 34 |
| 14 |
|
Ceará - CE | 28 | 6 | 15 | 7 | 26:30 | -4 | 33 |
| 15 |
|
Bahia - BA | 28 | 8 | 8 | 12 | 32:39 | -7 | 32 |
| 16 |
|
Santos FC | 28 | 7 | 11 | 10 | 25:34 | -9 | 32 |
| 17 |
|
Juventude - RS | 28 | 6 | 11 | 11 | 27:36 | -9 | 29 |
| 18 |
|
Grêmio Porto Alegre | 28 | 7 | 6 | 15 | 26:36 | -10 | 27 |
| 19 |
|
Sport Recife - PE | 28 | 6 | 9 | 13 | 15:24 | -9 | 27 |
| 20 |
|
Chapecoense | 28 | 1 | 10 | 17 | 24:49 | -25 | 13 |
| Copa Libertadores | |
| Kwalificatie | |
| Copa Sudamericana | |
| Degradatie |
