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| 05.03.2022 | 14:30 | ACR Messina | - | SS Juve Stabia | 0:1 (0:1) | |
| 17:30 | Calcio Catania | - | Monterosi FC | geannuleerd | ||
| 17:30 | Paganese Calcio | - | US Avellino | 0:2 (0:1) | ||
| 17:30 | Palermo FC | - | Vibonese Calcio | 3:0 (0:0) | ||
| 17:30 | SS Monopoli 1966 | - | US Catanzaro | 2:1 (2:1) | ||
| 17:30 | SSC Bari | - | Virtus Francavilla | 2:1 (1:0) | ||
| 17:30 | Taranto FC | - | Foggia Calcio | 1:1 (0:1) | ||
| 17:30 | Latina Calcio | - | Potenza | 0:3 (0:0) | ||
| 06.03.2022 | 17:30 | FC Turris | - | Fidelis Andria | 1:0 (0:0) | |
| 30.03.2022 | 18:00 | AZ Picerno | - | Campobasso | 3:2 (1:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 28 | 17 | 7 | 4 | 46:23 | 23 | 58 |
| 2 |
|
Virtus Francavilla | 28 | 16 | 4 | 8 | 39:22 | 17 | 52 |
| 3 |
|
Palermo FC | 29 | 14 | 9 | 6 | 49:27 | 22 | 51 |
| 4 |
|
US Catanzaro | 28 | 14 | 9 | 5 | 37:17 | 20 | 51 |
| 5 |
|
US Avellino | 28 | 13 | 12 | 3 | 37:19 | 18 | 51 |
| 6 |
|
FC Turris | 28 | 13 | 4 | 11 | 45:36 | 9 | 43 |
| 7 |
|
SS Monopoli 1966 | 28 | 12 | 7 | 9 | 28:25 | 3 | 43 |
| 8 |
|
Foggia Calcio | 29 | 9 | 13 | 7 | 43:37 | 6 | 40 |
| 9 |
|
AZ Picerno | 28 | 11 | 7 | 10 | 30:32 | -2 | 40 |
| 10 |
|
Latina Calcio | 29 | 11 | 6 | 12 | 35:37 | -2 | 39 |
| 11 |
|
SS Juve Stabia | 28 | 10 | 9 | 9 | 31:30 | 1 | 37 |
| 12 |
|
Monterosi FC | 28 | 9 | 10 | 9 | 32:35 | -3 | 37 |
| 13 |
|
Campobasso | 29 | 8 | 9 | 12 | 36:48 | -12 | 33 |
| 14 |
|
Taranto FC | 29 | 7 | 11 | 11 | 26:35 | -9 | 32 |
| 15 |
|
ACR Messina | 29 | 8 | 7 | 14 | 34:49 | -15 | 31 |
| 16 |
|
Potenza | 29 | 6 | 9 | 14 | 28:43 | -15 | 27 |
| 17 |
|
Paganese Calcio | 28 | 6 | 6 | 16 | 26:47 | -21 | 24 |
| 18 |
|
Fidelis Andria | 28 | 5 | 7 | 16 | 22:38 | -16 | 22 |
| 19 |
|
Vibonese Calcio | 29 | 3 | 10 | 16 | 21:45 | -24 | 19 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
