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| 16.03.2022 | 14:30 | ACR Messina | - | US Catanzaro | 2:3 (1:1) | |
| 14:30 | Taranto FC | - | US Avellino | 0:1 (0:0) | ||
| 15:00 | Palermo FC | - | Fidelis Andria | 1:1 (0:1) | ||
| 18:00 | SS Monopoli 1966 | - | Vibonese Calcio | 3:0 (2:0) | ||
| 21:00 | Calcio Catania | - | Campobasso | geannuleerd | ||
| 21:00 | Paganese Calcio | - | Foggia Calcio | 1:4 (0:0) | ||
| 21:00 | AZ Picerno | - | Potenza | 0:1 (0:0) | ||
| 21:00 | SSC Bari | - | SS Juve Stabia | 1:0 (0:0) | ||
| 21:00 | FC Turris | - | Monterosi FC | 0:2 (0:1) | ||
| 21:00 | Latina Calcio | - | Virtus Francavilla | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 30 | 19 | 7 | 4 | 49:24 | 25 | 64 |
| 2 |
|
Palermo FC | 31 | 15 | 10 | 6 | 52:29 | 23 | 55 |
| 3 |
|
US Catanzaro | 30 | 15 | 9 | 6 | 41:21 | 20 | 54 |
| 4 |
|
US Avellino | 30 | 14 | 12 | 4 | 39:21 | 18 | 54 |
| 5 |
|
Virtus Francavilla | 30 | 16 | 6 | 8 | 42:25 | 17 | 54 |
| 6 |
|
SS Monopoli 1966 | 30 | 14 | 7 | 9 | 32:25 | 7 | 49 |
| 7 |
|
Foggia Calcio | 31 | 11 | 13 | 7 | 50:40 | 10 | 46 |
| 8 |
|
FC Turris | 30 | 13 | 4 | 13 | 45:41 | 4 | 43 |
| 9 |
|
Latina Calcio | 31 | 11 | 8 | 12 | 36:38 | -2 | 41 |
| 10 |
|
SS Juve Stabia | 30 | 11 | 9 | 10 | 34:31 | 3 | 40 |
| 11 |
|
Monterosi FC | 30 | 10 | 10 | 10 | 34:36 | -2 | 40 |
| 12 |
|
AZ Picerno | 30 | 11 | 7 | 12 | 32:36 | -4 | 40 |
| 13 |
|
Campobasso | 30 | 9 | 9 | 12 | 38:48 | -10 | 36 |
| 14 |
|
Taranto FC | 31 | 7 | 12 | 12 | 27:37 | -10 | 33 |
| 15 |
|
Potenza | 31 | 7 | 10 | 14 | 30:44 | -14 | 31 |
| 16 |
|
ACR Messina | 31 | 8 | 7 | 16 | 36:54 | -18 | 31 |
| 17 |
|
Paganese Calcio | 30 | 6 | 7 | 17 | 30:54 | -24 | 25 |
| 18 |
|
Fidelis Andria | 30 | 5 | 9 | 16 | 24:40 | -16 | 24 |
| 19 |
|
Vibonese Calcio | 30 | 3 | 10 | 17 | 21:48 | -27 | 19 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
