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| 02.04.2022 | 17:30 | Paganese Calcio | - | SS Monopoli 1966 | 0:1 (0:1) | |
| 03.04.2022 | 14:30 | Palermo FC | - | AZ Picerno | 4:0 (1:0) | |
| 14:30 | US Catanzaro | - | Monterosi FC | 1:2 (0:0) | ||
| 17:30 | Fidelis Andria | - | ACR Messina | 0:0 (0:0) | ||
| 17:30 | Potenza | - | Calcio Catania | geannuleerd | ||
| 17:30 | Taranto FC | - | SS Juve Stabia | 0:0 (0:0) | ||
| 17:30 | Latina Calcio | - | SSC Bari | 0:1 (0:1) | ||
| 17:30 | Vibonese Calcio | - | Foggia Calcio | 1:1 (1:1) | ||
| 17:30 | Virtus Francavilla | - | Campobasso | 4:4 (3:1) | ||
| 04.04.2022 | 21:00 | US Avellino | - | FC Turris | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 33 | 21 | 8 | 4 | 51:24 | 27 | 71 |
| 2 |
|
US Avellino | 33 | 16 | 13 | 4 | 42:22 | 20 | 61 |
| 3 |
|
Palermo FC | 34 | 16 | 12 | 6 | 60:33 | 27 | 60 |
| 4 |
|
US Catanzaro | 33 | 16 | 10 | 7 | 45:24 | 21 | 58 |
| 5 |
|
Virtus Francavilla | 33 | 16 | 7 | 10 | 46:31 | 15 | 55 |
| 6 |
|
SS Monopoli 1966 | 33 | 16 | 7 | 10 | 36:28 | 8 | 55 |
| 7 |
|
Foggia Calcio | 33 | 12 | 14 | 7 | 56:43 | 13 | 50 |
| 8 |
|
Monterosi FC | 33 | 12 | 11 | 10 | 39:37 | 2 | 47 |
| 9 |
|
FC Turris | 33 | 14 | 4 | 15 | 46:44 | 2 | 46 |
| 10 |
|
AZ Picerno | 33 | 12 | 7 | 14 | 33:41 | -8 | 43 |
| 11 |
|
SS Juve Stabia | 33 | 11 | 11 | 11 | 35:35 | 0 | 42 |
| 12 |
|
Latina Calcio | 34 | 11 | 8 | 15 | 36:42 | -6 | 41 |
| 13 |
|
Campobasso | 33 | 10 | 10 | 13 | 46:57 | -11 | 40 |
| 14 |
|
Taranto FC | 33 | 8 | 13 | 12 | 29:37 | -8 | 37 |
| 15 |
|
ACR Messina | 34 | 9 | 9 | 16 | 38:55 | -17 | 36 |
| 16 |
|
Potenza | 33 | 7 | 11 | 15 | 33:49 | -16 | 32 |
| 17 |
|
Fidelis Andria | 33 | 6 | 11 | 16 | 25:40 | -15 | 29 |
| 18 |
|
Paganese Calcio | 33 | 6 | 8 | 19 | 32:58 | -26 | 26 |
| 19 |
|
Vibonese Calcio | 33 | 3 | 12 | 18 | 22:50 | -28 | 21 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
