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| 03.04.2022 | 15:00 | GSD Castelfidardo | - | Montegiorgio Calcio | 1:0 | |
| 15:00 | Castelnuovo Vomano | - | SN Notaresco | 2:2 | ||
| 15:00 | Alma Juventus Fano | - | Aurora Alto Casertano | 3:2 | ||
| 15:00 | Matese | - | Tolentino | 0:1 | ||
| 15:00 | Nereto | - | Atletico Terme Fiuggi | 0:1 | ||
| 15:00 | Porto D'Ascoli | - | ASD Trastevere | 0:3 | ||
| 15:00 | Vastese Calcio | - | ASD Pineto Calcio | 2:0 | ||
| 15:00 | Chieti Calcio | - | Sambenedettese | 1:1 | ||
| 04.05.2022 | 15:00 | Vastogirardi | - | US Recanatese | 0:2 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
US Recanatese | 27 | 17 | 6 | 4 | 56:16 | 40 | 57 |
| 2 |
|
ASD Trastevere | 27 | 14 | 6 | 7 | 44:26 | 18 | 48 |
| 3 |
|
Tolentino | 27 | 14 | 5 | 8 | 32:19 | 13 | 47 |
| 4 |
|
Atletico Terme Fiuggi | 27 | 13 | 5 | 9 | 36:35 | 1 | 44 |
| 5 |
|
SN Notaresco | 27 | 12 | 7 | 8 | 36:32 | 4 | 43 |
| 6 |
|
ASD Pineto Calcio | 27 | 10 | 11 | 6 | 34:20 | 14 | 41 |
| 7 |
|
Vastese Calcio | 27 | 10 | 11 | 6 | 35:26 | 9 | 41 |
| 8 |
|
Porto D'Ascoli | 27 | 11 | 7 | 9 | 33:30 | 3 | 40 |
| 9 |
|
Sambenedettese | 27 | 10 | 9 | 8 | 29:29 | 0 | 39 |
| 10 |
|
Chieti Calcio | 27 | 10 | 9 | 8 | 27:29 | -2 | 39 |
| 11 |
|
Montegiorgio Calcio | 27 | 10 | 6 | 11 | 30:29 | 1 | 36 |
| 12 |
|
Matese | 27 | 9 | 9 | 9 | 31:30 | 1 | 36 |
| 13 |
|
Castelnuovo Vomano | 27 | 9 | 8 | 10 | 42:44 | -2 | 35 |
| 14 |
|
Alma Juventus Fano | 27 | 9 | 7 | 11 | 31:31 | 0 | 34 |
| 15 |
|
Vastogirardi | 27 | 9 | 7 | 11 | 34:41 | -7 | 34 |
| 16 |
|
GSD Castelfidardo | 27 | 8 | 7 | 12 | 23:28 | -5 | 31 |
| 17 |
|
Nereto | 27 | 2 | 6 | 19 | 19:61 | -42 | 12 |
| 18 |
|
Aurora Alto Casertano | 27 | 1 | 4 | 22 | 14:60 | -46 | 7 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
