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| 20.02.2022 | 14:30 | US Bitonto | - | ASD SS Nola 1925 | 0:2 | |
| 14:30 | Brindisi | - | Sporting Fulgor Molfetta | 1:0 | ||
| 14:30 | Casertana FC | - | ACD Nardò | 3:0 | ||
| 14:30 | FC Francavilla | - | Città di Fasano | 3:1 | ||
| 14:30 | Lavello | - | Bisceglie | 2:0 | ||
| 14:30 | Mariglianese | - | Team Altamura | 1:0 | ||
| 14:30 | Rotonda | - | San Giorgio-Sedico | 0:0 | ||
| 14:30 | Virtus Matino | - | Casarano | 1:2 | ||
| 15:00 | ASG Nocerina | - | Sorrento Calcio | 3:0 | ||
| 15:00 | Audace Cerignola | - | FBC Gravina | 2:1 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Audace Cerignola | 25 | 16 | 7 | 2 | 55:20 | 35 | 55 |
| 2 |
|
US Bitonto | 25 | 16 | 4 | 5 | 41:24 | 17 | 52 |
| 3 |
|
FC Francavilla | 25 | 16 | 2 | 7 | 41:25 | 16 | 50 |
| 4 |
|
Città di Fasano | 25 | 13 | 5 | 7 | 48:34 | 14 | 44 |
| 5 |
|
FBC Gravina | 25 | 13 | 3 | 9 | 34:33 | 1 | 42 |
| 6 |
|
ASG Nocerina | 25 | 11 | 5 | 9 | 34:33 | 1 | 38 |
| 7 |
|
Casertana FC | 25 | 10 | 6 | 9 | 41:37 | 4 | 36 |
| 8 |
|
Sporting Fulgor Molfetta | 25 | 8 | 11 | 6 | 34:26 | 8 | 35 |
| 9 |
|
Sorrento Calcio | 25 | 9 | 7 | 9 | 25:34 | -9 | 34 |
| 10 |
|
Lavello | 25 | 9 | 6 | 10 | 35:36 | -1 | 33 |
| 11 |
|
ASD SS Nola 1925 | 25 | 8 | 6 | 11 | 29:36 | -7 | 30 |
| 12 |
|
Mariglianese | 25 | 8 | 5 | 12 | 28:30 | -2 | 29 |
| 13 |
|
ACD Nardò | 25 | 8 | 5 | 12 | 30:40 | -10 | 29 |
| 14 |
|
Casarano | 25 | 7 | 7 | 11 | 26:35 | -9 | 28 |
| 15 |
|
Team Altamura | 25 | 6 | 9 | 10 | 27:28 | -1 | 27 |
| 16 |
|
San Giorgio-Sedico | 25 | 6 | 9 | 10 | 18:24 | -6 | 27 |
| 17 |
|
Rotonda | 25 | 9 | 7 | 9 | 25:26 | -1 | 26 |
| 18 |
|
Bisceglie | 25 | 4 | 12 | 9 | 20:33 | -13 | 24 |
| 19 |
|
Brindisi | 25 | 6 | 6 | 13 | 20:38 | -18 | 24 |
| 20 |
|
Virtus Matino | 25 | 4 | 4 | 17 | 19:38 | -19 | 16 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
