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| 24.04.2022 | 15:00 | ACD Nardò | - | Brindisi | 2:4 | |
| 15:00 | Bisceglie | - | Sorrento Calcio | 3:1 | ||
| 15:00 | Casarano | - | San Giorgio-Sedico | 1:1 | ||
| 15:00 | Casertana FC | - | FC Francavilla | 0:1 | ||
| 15:00 | FBC Gravina | - | Rotonda | 0:1 | ||
| 15:00 | Lavello | - | Mariglianese | 0:1 | ||
| 15:00 | ASD SS Nola 1925 | - | Città di Fasano | 2:1 | ||
| 15:00 | Virtus Matino | - | ASG Nocerina | 2:1 | ||
| 16:00 | Audace Cerignola | - | US Bitonto | 1:0 | ||
| 17:00 | Team Altamura | - | Sporting Fulgor Molfetta | 2:3 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Audace Cerignola | 34 | 23 | 9 | 2 | 70:24 | 46 | 78 |
| 2 |
|
FC Francavilla | 34 | 20 | 4 | 10 | 53:37 | 16 | 64 |
| 3 |
|
US Bitonto | 34 | 17 | 8 | 9 | 48:35 | 13 | 59 |
| 4 |
|
Città di Fasano | 34 | 16 | 8 | 10 | 58:43 | 15 | 56 |
| 5 |
|
ASG Nocerina | 34 | 15 | 7 | 12 | 48:43 | 5 | 52 |
| 6 |
|
FBC Gravina | 34 | 15 | 6 | 13 | 45:45 | 0 | 51 |
| 7 |
|
Casertana FC | 34 | 14 | 8 | 12 | 53:50 | 3 | 50 |
| 8 |
|
Sorrento Calcio | 34 | 13 | 9 | 12 | 39:43 | -4 | 48 |
| 9 |
|
Sporting Fulgor Molfetta | 34 | 11 | 13 | 10 | 42:37 | 5 | 46 |
| 10 |
|
ASD SS Nola 1925 | 34 | 12 | 8 | 14 | 46:53 | -7 | 44 |
| 11 |
|
Brindisi | 34 | 12 | 7 | 15 | 35:47 | -12 | 43 |
| 12 |
|
Lavello | 34 | 11 | 9 | 14 | 44:48 | -4 | 42 |
| 13 |
|
Team Altamura | 34 | 10 | 11 | 13 | 43:41 | 2 | 41 |
| 14 |
|
Mariglianese | 34 | 11 | 7 | 16 | 37:41 | -4 | 40 |
| 15 |
|
Casarano | 34 | 10 | 10 | 14 | 33:44 | -11 | 40 |
| 16 |
|
Rotonda | 34 | 13 | 7 | 14 | 35:40 | -5 | 38 |
| 17 |
|
ACD Nardò | 34 | 10 | 8 | 16 | 47:59 | -12 | 38 |
| 18 |
|
San Giorgio-Sedico | 34 | 8 | 12 | 14 | 26:36 | -10 | 36 |
| 19 |
|
Bisceglie | 34 | 6 | 15 | 13 | 27:43 | -16 | 33 |
| 20 |
|
Virtus Matino | 34 | 7 | 6 | 21 | 29:49 | -20 | 27 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
