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| 31.10.2021 | 14:30 | ASG Nocerina | - | Casertana FC | 1:3 | |
| 14:30 | US Bitonto | - | Team Altamura | 2:1 | ||
| 14:30 | Brindisi | - | Città di Fasano | 0:1 | ||
| 14:30 | FC Francavilla | - | ASD SS Nola 1925 | 1:1 | ||
| 14:30 | Lavello | - | FBC Gravina | 3:3 | ||
| 14:30 | Mariglianese | - | Casarano | 2:0 | ||
| 14:30 | Rotonda | - | Sporting Fulgor Molfetta | 3:0 | ||
| 14:30 | Sorrento Calcio | - | San Giorgio-Sedico | 3:1 | ||
| 14:30 | Virtus Matino | - | Bisceglie | 0:1 | ||
| 15:00 | Audace Cerignola | - | ACD Nardò | 1:1 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
US Bitonto | 9 | 7 | 2 | 0 | 17:7 | 10 | 23 |
| 2 |
|
Casertana FC | 9 | 5 | 4 | 0 | 17:8 | 9 | 19 |
| 3 |
|
ASG Nocerina | 9 | 5 | 2 | 2 | 11:6 | 5 | 17 |
| 4 |
|
Lavello | 9 | 5 | 2 | 2 | 18:12 | 6 | 17 |
| 5 |
|
FC Francavilla | 9 | 5 | 1 | 3 | 15:8 | 7 | 16 |
| 6 |
|
Audace Cerignola | 9 | 4 | 3 | 2 | 18:8 | 10 | 15 |
| 7 |
|
Città di Fasano | 9 | 4 | 2 | 3 | 10:10 | 0 | 14 |
| 8 |
|
Sporting Fulgor Molfetta | 9 | 3 | 4 | 2 | 11:9 | 2 | 13 |
| 9 |
|
Mariglianese | 9 | 3 | 3 | 3 | 11:9 | 2 | 12 |
| 10 |
|
Casarano | 9 | 4 | 0 | 5 | 7:10 | -3 | 12 |
| 11 |
|
Bisceglie | 9 | 3 | 3 | 3 | 5:8 | -3 | 12 |
| 12 |
|
Sorrento Calcio | 9 | 3 | 3 | 3 | 8:13 | -5 | 12 |
| 13 |
|
FBC Gravina | 9 | 3 | 1 | 5 | 9:15 | -6 | 10 |
| 14 |
|
ASD SS Nola 1925 | 9 | 3 | 1 | 5 | 11:23 | -12 | 10 |
| 15 |
|
Rotonda | 9 | 5 | 2 | 2 | 13:6 | 7 | 9 |
| 16 |
|
Team Altamura | 9 | 2 | 2 | 5 | 10:13 | -3 | 8 |
| 17 |
|
Virtus Matino | 9 | 2 | 2 | 5 | 7:11 | -4 | 8 |
| 18 |
|
ACD Nardò | 9 | 2 | 2 | 5 | 10:13 | -3 | 8 |
| 19 |
|
San Giorgio-Sedico | 9 | 0 | 4 | 5 | 5:11 | -6 | 4 |
| 20 |
|
Brindisi | 9 | 0 | 1 | 8 | 4:17 | -13 | 1 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
