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| 01.04.2021 | 15:00 | ACR Messina | - | Roccella | 5:1 | |
| 15:00 | Biancavilla | - | Gelbison | 2:1 | ||
| 15:00 | Calcio Cittanovese | - | Rotonda | 1:1 | ||
| 15:00 | USD Ragusa | - | FC Messina | 3:3 | ||
| 15:00 | Rende | - | Paternó | 0:0 | ||
| 15:00 | Città Di S. Agata | - | US Castrovillari | 2:1 | ||
| 15:00 | Santa Maria Cilento | - | ASD San Luca | 3:2 | ||
| 15:00 | ASD Troina | - | Dattilo | 4:0 | ||
| 02.05.2021 | 15:00 | Licata | - | Acireale | 1:0 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
ACR Messina | 24 | 14 | 8 | 2 | 43:18 | 25 | 50 |
| 2 |
|
FC Messina | 24 | 14 | 6 | 4 | 35:17 | 18 | 48 |
| 3 |
|
Gelbison | 24 | 12 | 8 | 4 | 38:25 | 13 | 44 |
| 4 |
|
Acireale | 24 | 13 | 2 | 9 | 40:24 | 16 | 41 |
| 5 |
|
ASD San Luca | 24 | 12 | 5 | 7 | 30:24 | 6 | 41 |
| 6 |
|
Rotonda | 24 | 10 | 7 | 7 | 22:23 | -1 | 37 |
| 7 |
|
Licata | 24 | 10 | 5 | 9 | 25:22 | 3 | 35 |
| 8 |
|
Dattilo | 24 | 11 | 2 | 11 | 39:38 | 1 | 35 |
| 9 |
|
Biancavilla | 24 | 11 | 2 | 11 | 29:29 | 0 | 34 |
| 10 |
|
Santa Maria Cilento | 24 | 7 | 10 | 7 | 32:22 | 10 | 31 |
| 11 |
|
ASD Troina | 24 | 8 | 6 | 10 | 21:30 | -9 | 30 |
| 12 |
|
Calcio Cittanovese | 24 | 7 | 8 | 9 | 31:37 | -6 | 29 |
| 13 |
|
Paternó | 24 | 7 | 7 | 10 | 19:23 | -4 | 28 |
| 14 |
|
US Castrovillari | 24 | 6 | 9 | 9 | 24:24 | 0 | 27 |
| 15 |
|
Città Di S. Agata | 24 | 6 | 9 | 9 | 21:30 | -9 | 27 |
| 16 |
|
Rende | 24 | 5 | 6 | 13 | 23:40 | -17 | 21 |
| 17 |
|
USD Ragusa | 24 | 4 | 8 | 12 | 26:43 | -17 | 20 |
| 18 |
|
Roccella | 24 | 4 | 2 | 18 | 13:42 | -29 | 14 |
| Promotie | |
| Play-offs | |
| Degradatie |
