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| 12.03.2022 | 11:30 | Hatayspor | - | Fatih Karagümrük SK | 3:0 (2:0) | |
| 14:00 | Altay Izmir | - | Yeni Malatyaspor | 1:0 (1:0) | ||
| 14:00 | Kasımpaşa SK | - | Çaykur Rizespor | 3:1 (1:0) | ||
| 17:00 | Trabzonspor | - | Göztepe | 4:2 (2:2) | ||
| 13.03.2022 | 11:30 | Kayserispor | - | Konyaspor | 2:3 (2:1) | |
| 14:00 | Adana Demirspor | - | Sivasspor | 2:3 (0:1) | ||
| 17:00 | Alanyaspor | - | Fenerbahçe | 2:5 (0:1) | ||
| 14.03.2022 | 14:00 | İstanbul Başakşehir | - | Antalyaspor | 0:1 (0:1) | |
| 18:00 | Galatasaray | - | Beşiktaş | 2:1 (2:0) | ||
| 18:00 | Giresunspor | - | Gaziantep FK | 2:1 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 29 | 21 | 7 | 1 | 56:23 | 33 | 70 |
| 2 |
|
Konyaspor | 29 | 16 | 7 | 6 | 47:31 | 16 | 55 |
| 3 |
|
Fenerbahçe | 29 | 14 | 8 | 7 | 48:34 | 14 | 50 |
| 4 |
|
İstanbul Başakşehir | 29 | 14 | 5 | 10 | 41:29 | 12 | 47 |
| 5 |
|
Alanyaspor | 29 | 13 | 7 | 9 | 53:47 | 6 | 46 |
| 6 |
|
Hatayspor | 29 | 14 | 4 | 11 | 47:45 | 2 | 46 |
| 7 |
|
Adana Demirspor | 29 | 12 | 9 | 8 | 44:31 | 13 | 45 |
| 8 |
|
Beşiktaş | 29 | 12 | 9 | 8 | 43:38 | 5 | 45 |
| 9 |
|
Fatih Karagümrük SK | 29 | 11 | 7 | 11 | 33:43 | -10 | 40 |
| 10 |
|
Kayserispor | 29 | 10 | 8 | 11 | 43:45 | -2 | 38 |
| 11 |
|
Galatasaray | 29 | 10 | 8 | 11 | 39:42 | -3 | 38 |
| 12 |
|
Antalyaspor | 29 | 10 | 8 | 11 | 30:35 | -5 | 38 |
| 13 |
|
Sivasspor | 29 | 9 | 10 | 10 | 38:37 | 1 | 37 |
| 14 |
|
Gaziantep FK | 29 | 10 | 7 | 12 | 37:41 | -4 | 37 |
| 15 |
|
Kasımpaşa SK | 29 | 9 | 8 | 12 | 43:43 | 0 | 35 |
| 16 |
|
Giresunspor | 29 | 10 | 5 | 14 | 31:33 | -2 | 35 |
| 17 |
|
Altay Izmir | 29 | 8 | 5 | 16 | 30:41 | -11 | 29 |
| 18 |
|
Göztepe | 29 | 7 | 6 | 16 | 36:48 | -12 | 27 |
| 19 |
|
Çaykur Rizespor | 29 | 6 | 5 | 18 | 26:53 | -27 | 23 |
| 20 |
|
Yeni Malatyaspor | 29 | 5 | 5 | 19 | 23:49 | -26 | 20 |
| Champions League | |
| Champions League Kwali. | |
| Degradatie |
