| 1. Ronde | 14.08.2021 | Hatayspor | - | Kasımpaşa SK | 1:1 | ||||
| 2. Ronde | 23.08.2021 | Galatasaray | - | Hatayspor | 2:1 | ||||
| 3. Ronde | 28.08.2021 | Hatayspor | - | Alanyaspor | 5:0 |  |
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| 4. Ronde | 12.09.2021 | Çaykur Rizespor | - | Hatayspor | 0:2 | ||||
| 5. Ronde | 19.09.2021 | Hatayspor | - | Kayserispor | 2:1 | ||||
| 6. Ronde | 22.09.2021 | Göztepe | - | Hatayspor | 0:2 | ||||
| 7. Ronde | 26.09.2021 | Hatayspor | - | Fenerbahçe | 1:2 | ||||
| 8. Ronde | 03.10.2021 | Yeni Malatyaspor | - | Hatayspor | 0:2 | ||||
| 9. Ronde | 18.10.2021 | Hatayspor | - | Gaziantep FK | 2:1 | ||||
| 10. Ronde | 24.10.2021 | Fatih Karagümrük | - | Hatayspor | 1:1 | ||||
| 11. Ronde | 30.10.2021 | Hatayspor | - | Beşiktaş | 1:0 | |
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| 12. Ronde | 07.11.2021 | Adana Demirspor | - | Hatayspor | 1:0 | ||||
| 13. Ronde | 20.11.2021 | Hatayspor | - | Antalyaspor | 3:1 | ||||
| 14. Ronde | 28.11.2021 | Sivasspor | - | Hatayspor | 4:0 | ||||
| 15. Ronde | 05.12.2021 | Hatayspor | - | İstanbul Başakşehir | 0:3 | |
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| 19. Ronde | 25.12.2021 | Giresunspor | - | Hatayspor | 0:1 | ||||
| 24. Ronde | 04.02.2022 | Kayserispor | - | Hatayspor | 4:3 | |
Mali