| 6. Ronde | 26.10.2021 | Doncaster Rovers | - | Cambridge United | 1:1 | ||||
| 12. Ronde | 02.11.2021 | Morecambe FC | - | Cambridge United | 0:2 |  |
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| 19. Ronde | 23.11.2021 | Cambridge United | - | Wigan Athletic | 2:2 | ||||
| 22. Ronde | 11.12.2021 | Charlton Athletic | - | Cambridge United | 2:0 | ||||
| 26. Ronde | 03.01.2022 | Cambridge United | - | Portsmouth FC | 0:0 | ||||
| 28. Ronde | 15.01.2022 | Lincoln City | - | Cambridge United | 0:1 | ||||
| 25. Ronde | 18.01.2022 | Cambridge United | - | Doncaster Rovers | 3:1 | ||||
| 29. Ronde | 22.01.2022 | Cambridge United | - | Crewe Alexandra | 1:0 | ||||
| 27. Ronde | 01.02.2022 | Bolton Wanderers | - | Cambridge United | 2:0 | ||||
| 35. Ronde | 22.02.2022 | Cambridge United | - | Plymouth Argyle | 2:0 | ||||
| 24. Ronde | 01.03.2022 | Wycombe Wanderers | - | Cambridge United | 3:0 | ||||
| 31. Ronde | 05.04.2022 | Cambridge United | - | Wycombe Wanderers | 1:4 | ||||
| 44. Ronde | 19.04.2022 | Cambridge United | - | Charlton Athletic | 0:2 |
Engeland