| 11. Ronde | 09.10.2021 | Bristol Rovers | - | Carlisle United | 3:0 |  |
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| 17. Ronde | 20.11.2021 | Exeter City | - | Carlisle United | 2:1 | ||||
| 18. Ronde | 23.11.2021 | Carlisle United | - | Harrogate Town | 0:2 | ||||
| 20. Ronde | 07.12.2021 | Mansfield Town | - | Carlisle United | 1:0 | ||||
| 21. Ronde | 11.12.2021 | Stevenage FC | - | Carlisle United | 0:2 | ||||
| 25. Ronde | 01.01.2022 | Scunthorpe United | - | Carlisle United | 0:1 | ||||
| 31. Ronde | 08.02.2022 | Carlisle United | - | Port Vale FC | 1:3 | ||||
| 23. Ronde | 01.03.2022 | Carlisle United | - | Rochdale AFC | 2:0 | ||||
| 35. Ronde | 05.03.2022 | Oldham Athletic | - | Carlisle United | 1:2 | ||||
| 37. Ronde | 15.03.2022 | Carlisle United | - | Newport County | 1:2 | ||||
| 38. Ronde | 19.03.2022 | Barrow AFC | - | Carlisle United | 1:2 | ||||
| 39. Ronde | 26.03.2022 | Carlisle United | - | Bristol Rovers | 1:0 | ||||
| 30. Ronde | 29.03.2022 | Rochdale AFC | - | Carlisle United | 2:0 | |
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| 40. Ronde | 02.04.2022 | Tranmere Rovers | - | Carlisle United | 2:2 | ||||
| 41. Ronde | 09.04.2022 | Carlisle United | - | Exeter City | 0:1 | ||||
| 43. Ronde | 18.04.2022 | Carlisle United | - | Mansfield Town | 1:0 | ||||
| 44. Ronde | 23.04.2022 | Harrogate Town | - | Carlisle United | 3:0 | |
Engeland