| 1. Ronde | 07.08.2021 | Salford City | - | Leyton Orient | 1:1 | ||||
| 2. Ronde | 14.08.2021 | Leyton Orient | - | Exeter City | 3:0 | ||||
| 4. Ronde | 21.08.2021 | Carlisle United | - | Leyton Orient | 1:1 | ||||
| 3. Ronde | 24.08.2021 | Leyton Orient | - | Harrogate Town | 0:2 | ||||
| 7. Ronde | 11.09.2021 | Leyton Orient | - | Oldham Athletic | 4:0 | ||||
| 8. Ronde | 18.09.2021 | Bristol Rovers | - | Leyton Orient | 1:3 | ||||
| 10. Ronde | 02.10.2021 | Port Vale FC | - | Leyton Orient | 3:2 | ||||
| 21. Ronde | 11.12.2021 | Leyton Orient | - | Crawley Town | 1:2 |  |
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| 22. Ronde | 18.12.2021 | Tranmere Rovers | - | Leyton Orient | 1:0 | |
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| 29. Ronde | 29.01.2022 | Mansfield Town | - | Leyton Orient | 2:0 | ||||
| 26. Ronde | 01.02.2022 | Bradford City | - | Leyton Orient | 1:1 | ||||
| 31. Ronde | 08.02.2022 | Exeter City | - | Leyton Orient | 1:0 |
Engeland