| 7. Ronde | 18.09.2021 | FC Speyer 09 | - | FSV Jägersburg | 0:5 | ||||
| 8. Ronde | 22.09.2021 | SV Röchling Völklingen | - | FC Speyer 09 | 3:1 | ||||
| 9. Ronde | 26.09.2021 | FC Speyer 09 | - | FV 07 Diefflen | 3:4 | ||||
| 10. Ronde | 02.10.2021 | FV Eppelborn | - | FC Speyer 09 | 2:1 |  |
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| 4. Ronde | 05.10.2021 | Arminia Ludwigshafen | - | FC Speyer 09 | 3:2 | ||||
| 11. Ronde | 10.10.2021 | FC Speyer 09 | - | FC Hertha Wiesbach | 1:2 | ||||
| 12. Ronde | 18.10.2021 | FC Speyer 09 | - | TuS Mechtersheim | 2:3 | |
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| 13. Ronde | 23.10.2021 | Wormatia Worms | - | FC Speyer 09 | 2:0 | |
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| 14. Ronde | 27.10.2021 | TSG Pfeddersheim | - | FC Speyer 09 | 3:3 | ||||
| 15. Ronde | 31.10.2021 | FC Speyer 09 | - | Arminia Ludwigshafen | 3:4 | ||||
| 16. Ronde | 08.11.2021 | FV Dudenhofen | - | FC Speyer 09 | 5:2 | ||||
| 17. Ronde | 14.11.2021 | FC Speyer 09 | - | SV 07 Elversberg II | 2:3 | ||||
| 18. Ronde | 20.11.2021 | FSV Jägersburg | - | FC Speyer 09 | 4:2 | ||||
| 20. Ronde | 27.11.2021 | FV 07 Diefflen | - | FC Speyer 09 | 2:1 | ||||
| 21. Ronde | 26.02.2022 | FC Speyer 09 | - | FV Eppelborn | 1:2 | ||||
| 22. Ronde | 05.03.2022 | FC Hertha Wiesbach | - | FC Speyer 09 | 8:1 |
Duitsland