| 1. Ronde | 16.08.2021 | FC Cartagena | - | UD Almería | 1:3 |  |
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| 2. Ronde | 22.08.2021 | SD Huesca | - | FC Cartagena | 2:0 | ||||
| 3. Ronde | 30.08.2021 | Real Zaragoza | - | FC Cartagena | 0:1 | ||||
| 4. Ronde | 04.09.2021 | FC Cartagena | - | Real Sociedad B | 1:0 | ||||
| 5. Ronde | 12.09.2021 | Real Oviedo | - | FC Cartagena | 2:0 | |
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| 6. Ronde | 18.09.2021 | FC Cartagena | - | CD Lugo | 2:1 | |
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| 7. Ronde | 27.09.2021 | CF Fuenlabrada | - | FC Cartagena | 2:1 | ||||
| 8. Ronde | 03.10.2021 | UD Las Palmas | - | FC Cartagena | 4:1 | |
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| 9. Ronde | 10.10.2021 | FC Cartagena | - | UD Ibiza | 5:1 | |
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| 11. Ronde | 19.10.2021 | FC Cartagena | - | Sporting Gijón | 1:0 | ||||
| 13. Ronde | 30.10.2021 | FC Cartagena | - | SD Ponferradina | 0:1 | ||||
| 14. Ronde | 02.11.2021 | CD Leganés | - | FC Cartagena | 1:1 | |
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| 15. Ronde | 07.11.2021 | FC Cartagena | - | Málaga CF | 3:1 | |
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| 16. Ronde | 14.11.2021 | Girona FC | - | FC Cartagena | 2:0 | |
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| 17. Ronde | 21.11.2021 | FC Cartagena | - | Burgos CF | 1:0 | |
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| 18. Ronde | 27.11.2021 | Real Valladolid | - | FC Cartagena | 2:0 |
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