| 1. Ronde | 06.08.2005 | Southampton FC | - | Wolverhampton Wanderers | 0:0 | ||||
| 2. Ronde | 09.08.2005 | Luton Town | - | Southampton FC | 3:2 | ||||
| 3. Ronde | 13.08.2005 | Sheffield Wednesday | - | Southampton FC | 0:1 | ||||
| 4. Ronde | 20.08.2005 | Southampton FC | - | Norwich City | 1:0 | ||||
| 5. Ronde | 27.08.2005 | Southampton FC | - | Crewe Alexandra | 2:0 | ||||
| 6. Ronde | 29.08.2005 | Coventry City | - | Southampton FC | 1:1 |  |
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| 7. Ronde | 10.09.2005 | Southampton FC | - | Queens Park Rangers | 1:1 | ||||
| 22. Ronde | 03.12.2005 | Southampton FC | - | Burnley FC | 1:1 | ||||
| 23. Ronde | 11.12.2005 | Southampton FC | - | Luton Town | 1:0 | ||||
| 24. Ronde | 17.12.2005 | Norwich City | - | Southampton FC | 3:1 | ||||
| 25. Ronde | 26.12.2005 | Watford FC | - | Southampton FC | 3:0 | ||||
| 27. Ronde | 31.12.2005 | Cardiff City | - | Southampton FC | 2:1 | ||||
| 28. Ronde | 02.01.2006 | Southampton FC | - | Brighton & Hove Albion | 2:1 | ||||
| 29. Ronde | 14.01.2006 | Queens Park Rangers | - | Southampton FC | 1:0 | ||||
| 30. Ronde | 21.01.2006 | Southampton FC | - | Ipswich Town | 0:2 | ||||
| 17. Ronde | 25.01.2006 | Southampton FC | - | Crystal Palace | 0:0 | |
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| 46. Ronde | 30.04.2006 | Southampton FC | - | Leicester City | 2:0 |
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