| 1. Ronde | 07.08.2021 | Northampton Town | - | Port Vale FC | 1:0 | ||||
| 2. Ronde | 14.08.2021 | Port Vale FC | - | Tranmere Rovers | 0:0 | ||||
| 3. Ronde | 17.08.2021 | Port Vale FC | - | Carlisle United | 0:0 | ||||
| 4. Ronde | 21.08.2021 | Stevenage FC | - | Port Vale FC | 1:1 |  |
|||
| 5. Ronde | 28.08.2021 | Forest Green Rovers | - | Port Vale FC | 0:2 | ||||
| 6. Ronde | 04.09.2021 | Port Vale FC | - | Rochdale AFC | 2:3 | ||||
| 7. Ronde | 11.09.2021 | Swindon Town | - | Port Vale FC | 1:2 | ||||
| 13. Ronde | 19.10.2021 | Mansfield Town | - | Port Vale FC | 1:1 | ||||
| 14. Ronde | 23.10.2021 | Port Vale FC | - | Colchester United | 3:0 | ||||
| 16. Ronde | 13.11.2021 | Port Vale FC | - | Bradford City | 1:1 | ||||
| 17. Ronde | 20.11.2021 | Oldham Athletic | - | Port Vale FC | 3:2 | ||||
| 18. Ronde | 23.11.2021 | Port Vale FC | - | Walsall FC | 0:1 | ||||
| 19. Ronde | 27.11.2021 | Port Vale FC | - | Hartlepool United | 2:0 | ||||
| 20. Ronde | 07.12.2021 | Bristol Rovers | - | Port Vale FC | 1:2 |
Engeland