| 5. Ronde | 19.09.2021 | Southampton FC U23 | - | Burnley FC U23 | 0:2 | ||||
| 6. Ronde | 27.09.2021 | Birmingham City U23 | - | Southampton FC U23 | 3:2 |  |
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| 7. Ronde | 01.10.2021 | Southampton FC U23 | - | Stoke City U23 | 1:1 | ||||
| 9. Ronde | 25.10.2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | |
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| 12. Ronde | 21.11.2021 | Sunderland AFC U23 | - | Southampton FC U23 | 3:2 | |
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| 15. Ronde | 17.12.2021 | Norwich City U23 | - | Southampton FC U23 | 4:3 | |
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| 17. Ronde | 17.01.2022 | Southampton FC U23 | - | Fulham FC U23 | 2:1 | |
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| 18. Ronde | 23.01.2022 | Southampton FC U23 | - | Middlesbrough FC U23 | 1:0 |
Engeland