| 10. Ronde | 06.02.2022 | Preußen Münster [A-jun] | - | FC Schalke 04 [A-jun] | 1:3 |  |
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| 12. Ronde | 20.02.2022 | Rot-Weiß Oberhausen [A-jun] | - | FC Schalke 04 [A-jun] | 0:2 | ||||
| 13. Ronde | 05.03.2022 | FC Schalke 04 [A-jun] | - | SC Paderborn 07 [A-jun] | 1:0 | ||||
| 14. Ronde | 02.04.2022 | Fortuna Köln [A-jun] | - | FC Schalke 04 [A-jun] | 0:3 | ||||
| 15. Ronde | 09.04.2022 | FC Schalke 04 [A-jun] | - | MSV Duisburg [A-jun] | 1:0 | |
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| 16. Ronde | 23.04.2022 | Arminia Bielefeld [A-jun] | - | FC Schalke 04 [A-jun] | 0:3 |
Duitsland