| 2. Ronde | 18.09.2021 | Bayer Leverkusen [A-jun] | - | MSV Duisburg [A-jun] | 2:2 | ||||
| 7. Ronde | 31.10.2021 | MSV Duisburg [A-jun] | - | VfL Bochum [A-jun] | 0:0 | ||||
| 9. Ronde | 05.12.2021 | MSV Duisburg [A-jun] | - | Rot-Weiss Essen [A-jun] | 3:0 | ||||
| 10. Ronde | 06.02.2022 | Rot-Weiß Oberhausen [A-jun] | - | MSV Duisburg [A-jun] | 1:1 | ||||
| 11. Ronde | 13.02.2022 | MSV Duisburg [A-jun] | - | SC Paderborn 07 [A-jun] | 0:0 | ||||
| 12. Ronde | 20.02.2022 | Fortuna Köln [A-jun] | - | MSV Duisburg [A-jun] | 2:4 |  |
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| 14. Ronde | 03.04.2022 | MSV Duisburg [A-jun] | - | Arminia Bielefeld [A-jun] | 4:0 | ||||
| 15. Ronde | 09.04.2022 | FC Schalke 04 [A-jun] | - | MSV Duisburg [A-jun] | 1:0 | ||||
| 16. Ronde | 23.04.2022 | MSV Duisburg [A-jun] | - | 1. FC Köln [A-jun] | 2:1 | |
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| 17. Ronde | 30.04.2022 | Fortuna Düsseldorf [A-jun] | - | MSV Duisburg [A-jun] | 1:2 | |
Duitsland