| 10. Ronde | 05.02.2022 | SC Paderborn 07 [A-jun] | - | Fortuna Köln [A-jun] | 4:0 |  |
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| 11. Ronde | 13.02.2022 | MSV Duisburg [A-jun] | - | SC Paderborn 07 [A-jun] | 0:0 | ||||
| 12. Ronde | 19.02.2022 | SC Paderborn 07 [A-jun] | - | Arminia Bielefeld [A-jun] | 3:2 | |
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| 13. Ronde | 05.03.2022 | FC Schalke 04 [A-jun] | - | SC Paderborn 07 [A-jun] | 1:0 | ||||
| 14. Ronde | 02.04.2022 | SC Paderborn 07 [A-jun] | - | 1. FC Köln [A-jun] | 0:0 | ||||
| 15. Ronde | 10.04.2022 | Fortuna Düsseldorf [A-jun] | - | SC Paderborn 07 [A-jun] | 0:2 | ||||
| 16. Ronde | 23.04.2022 | SC Paderborn 07 [A-jun] | - | Alemannia Aachen [A-jun] | 3:1 | ||||
| 17. Ronde | 30.04.2022 | Bayer Leverkusen [A-jun] | - | SC Paderborn 07 [A-jun] | 2:2 |
Rusland