| 25. Ronde | 21.01.2022 | Southend United | - | King's Lynn | 2:1 | ||||
| 26. Ronde | 25.01.2022 | Aldershot Town | - | Southend United | 1:1 |  |
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| 27. Ronde | 29.01.2022 | Dover Athletic | - | Southend United | 0:1 | ||||
| 23. Ronde | 08.02.2022 | Southend United | - | Bromley FC | 2:0 | ||||
| 29. Ronde | 12.02.2022 | Woking FC | - | Southend United | 2:3 | |
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| 31. Ronde | 22.02.2022 | Eastleigh FC | - | Southend United | 1:1 |  |
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| 37. Ronde | 26.03.2022 | Yeovil Town | - | Southend United | 2:0 | ||||
| 39. Ronde | 09.04.2022 | Stockport County | - | Southend United | 5:0 | ||||
| 40. Ronde | 15.04.2022 | Southend United | - | Wealdstone FC | 0:1 | ||||
| 41. Ronde | 18.04.2022 | Barnet FC | - | Southend United | 1:3 | |
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| 42. Ronde | 23.04.2022 | Southend United | - | Halifax Town | 1:0 | ||||
| 28. Ronde | 26.04.2022 | Southend United | - | Boreham Wood | 1:0 | |
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| 43. Ronde | 30.04.2022 | Wrexham AFC | - | Southend United | 1:0 | ||||
| 44. Ronde | 02.05.2022 | Southend United | - | Weymouth FC | 1:1 |
Schotland